| Project/Area Number |
26670835
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Tohoku University |
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Principal Investigator |
Egusa Hiroshi 東北大学, 歯学研究科(研究院), 教授 (30379078)
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| Co-Investigator(Renkei-kenkyūsha) |
YATANI Hirofumi 大阪大学, 大学院歯学研究科, 教授 (80174530)
FUKUMOTO Satoshi 東北大学, 大学院歯学研究科, 教授 (30264253)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨補填材 / iPS細胞 / 再生歯学 / 再生医学 / 歯学 / 骨組織再生 |
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| Outline of Final Research Achievements |
iPS cells can be infinitely expanded and guided to differentiate into osteogenic cells. In this research project, we attempted to fabricate bone graft materials by inactivation of osteogenically-induced iPS cells. Embryoid bodies of mouse gingiva-derived iPS cells were used to fabricate osteogenic iPS cell constructs. We found that the size and calcium production of mouse gingiva-derived iPS cell constructs can be controlled under a floating culture condition to provide suitable characteristics as a bone grafting material that enables bone regeneration in an animal model.
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