| Project/Area Number |
26670836
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Hokkaido University |
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Principal Investigator |
YOSHIDA Yasuhiro 北海道大学, 歯学研究科(研究院), 教授 (90281162)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | インプラント / インプラント周囲炎 / ドラッグデリバリーシステム / DDS / 殺菌剤 / CPC / 濃度 / 会合 |
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| Outline of Final Research Achievements |
Dental implants have become modern option for dentists toreplace missing teeth, resulting in an increasing percentage of the adult population with implant supported prosthesis. However, they have still some serious problems. For example, peri-implantitis iswell-known as a destructive inflammatory disease throughinfectious of soft and hard tissuessurrounding dental implants. It causes bone loss around an osseointegrated implant with increasing risk of implant failure.Therefore, we developed experimental materials containing cetylpyridinium chloride (CPC) and phophopullulan to prevent and treat peri-implantitis. Microbiological examination revealed that Ti treated with the experimental materials showed excellent antibacterial effect. These results are useful to develop new commercially available antibacterial materials for prevention and treatment of peri-implantitis.
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