| Project/Area Number |
26670839
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Kyushu University |
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Principal Investigator |
Atsuta Ikiru 九州大学, 大学病院, 助教 (30423487)
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| Co-Investigator(Kenkyū-buntansha) |
KOYANO Kiyoshi 九州大学, 大学院歯学研究院口腔機能修復学講座インプラント・義歯補綴科 (50195872)
AYUKAWA Yasunori 九州大学, 大学院歯学研究院口腔機能修復学講座インプラント・義歯補綴科 (50304697)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 上皮細胞 / 細胞接着 / チタンインプラント / 間葉系幹細胞 / 微小環境 / インプラント / 上皮封鎖性 |
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| Outline of Final Research Achievements |
Implant designs that can stimulate and integrate with an epithelial wound healing process may significantly enhance the efficacy of dental implants. Here, we investigated the effect of systemic Mesenchymal Stem Cells (MSC) transplantation on peri-implant epithelial sealing. Systemic MSC transplantation may be effective for enhancing epithelial sealing around titanium implants.In addition, the peri-implant epithelium condition on the implant body was investigated in vitro study. Rat oral epithelial cells (OECs) were co-cultured with MSC. We also identified an increase in the number of attached OECs upon direct or indirect co-culture with MSCs, and OEC apoptosis increased in co-culture with MSCs.
Collectively, our data suggest that systemic MSCs accumulate around the implant in the early stage and promote PIE formation and soft tissue attachment to the implant surface.
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