| Project/Area Number |
26670847
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGAI Akiko 東京医科歯科大学, 生体材料工学研究所, 准教授 (40360599)
NAKAMURA Miho 東京医科歯科大学, 生体材料工学研究所, 准教授 (40401385)
HORIUCHI Naohiro 東京医科歯科大学, 生体材料工学研究所, 助教 (90598195)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | バイオセラミックス / リン酸カルシウム / ハイドロキシアパタイト / 水酸アパタイト / 電気分極 / スキャホールド / 足場材料 / 硬組織代替 / 硬組織代替デバイス |
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| Outline of Final Research Achievements |
This study is aim to develop a new bone regeneration method that concurrently uses artificial materials and autogenous bone graft. The electrical polarization method that out group have been proposing is employed on both bioceramic materials and autogenous bone that is extracted during the operation. As a result, an improvement of biocompatibility and osteoconductivity are expected. We investigated the electrical properties of bone (collagen fibrils and apatite minerals) and found that bone can be electrically polarized by an external voltage. In addition, we also investigated the surface properties of hydroxyapatite that was artificially fabricated. Surface charges that were induced by the poling method were evaluated by the Kelvin probe method. We confirmed the mechanism that the surface charges on the polarized hydroxyapatite are induced by the polarization which is formed by the polarization process and uniformly distributed in the polarized material.
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