Minimally invasive therapy for the lymph node metastasis of oral cancer using the gold nanoparticles and near-infrared light
| Project/Area Number |
26670856
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
MORI SHIRO 東北大学, 大学病院, 講師 (80230069)
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| Co-Investigator(Kenkyū-buntansha) |
OKAJIMA Junnosuke 東北大学, 流体科学研究所, 助教 (70610161)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 口腔癌 / リンパ節転移 / 転移モデル / 金ナノロッド / 近赤外線レーザー |
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| Outline of Final Research Achievements |
Irradiation of near-infrared laser light to the gold nanorods (GNRs) induces the surface plasmon resonance heating. To develop a minimally invasive therapy for the metastatic lymph node (LN) of oral cancer, photothermal therapy by using the surface plasmon resonance heating was tested. In this study, we used MXH10/Mo/lpr mice whose LNs enlarged to about 10 mm in diameter as a model for LN metastasis. When the GNRs were injected into the metastatic LN of the mouse model, and then a near-infrared laser light were irradiated to the LN, anti-cancer effect was observed. However, burn of skin on the LN was induced by the irradiation of a near-infrared laser light. To overcome the side effect, we developed cooling system using circulation of cold water to suppress increasing temperature of the skin during the irradiation. Under the control of skin temperature by using this cooling system, burn of the skin after the laser irradiation was completely suppressed.
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Report
(3 results)
Research Products
(48 results)
