Strategic research on development of bone regenerative therapy with in vivo delivery of nucleic acids
| Project/Area Number |
26670859
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大庭 伸介 東京大学, 大学院工学系研究科(工学部), 准教授 (20466733)
星 和人 東京大学, 医学部附属病院, 准教授 (30344451)
藤原 夕子 東京大学, 医学部附属病院, 助教 (50466744)
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| Co-Investigator(Renkei-kenkyūsha) |
TEI Yuichi 東京大学, 大学院工学系研究科(工学部), 教授 (30345053)
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| Research Collaborator |
Hailati Aini
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 骨再生 / シグナル伝達 |
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| Outline of Final Research Achievements |
This study aimed to examine the potential of the skeletal tissue repair by nucleic acid delivery to cells around tissue defects, and to develop basic technologies to achieve the therapy. First, nanomicelles encapsulating nucleic acids were optimized. Second, functional biomaterials carrying the nanomicelles were examined for their use in tissue repair. Lastly, in vivo experiments using the animal model of skeletal tissue degeneration revealed that the administration of nanomicelles encapsulating nucleic acids of a skeletogenesis-related factor suppressed the degeneration and repaired the degenerated tissues. Thus, this study provides a proof of concept for the skeletal tissue repair using nanomicelles that encapsulate nucleic acids of therapeutic genes.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] 8.Kanno Y, Nakatsuka T, Saijo H, Fujihara Y, Atsuhiko H, Chung U, Takato T, Hoshi K.2016
Author(s)
Kanno Y, Nakatsuka T, Saijo H, Fujihara Y, Atsuhiko H, Chung U, Takato T, Hoshi K.
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Journal Title
Computed tomographic evaluation of novel custom-made artificial bones, “CT-bone”, applied for maxillofacial reconstruction.
Volume: 5
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Production of three-dimensional tissue-engineered cartilage through mutual fusion of chondrocyte pellets.2016
Author(s)
Hoshi K, Fujihara Y, Mori Y, Asawa Y, Kanazawa S, Nishizawa S, Misawa M, Numano T, Inoue H, Sakamoto T, Watanabe M, Komura M, Takato T.
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Journal Title
Int J Oral Maxillofac Surg.
Volume: Sep; 45(9)
Issue: 9
Pages: 1177-1185
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Preclinical and clinical research on bone and cartilage regenerative medicine in oral and maxillofacial region.2014
Author(s)
Takato T, Mori Y, Fujihara Y, Asawa Y, Nishizawa S, Kanazawa S, Ogasawara T, Saijo H, Abe T, Abe M, Suenaga H, Kanno Y, Sugiyama M, Hoshi K
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Journal Title
Oral Sci Int
Volume: 11(2)
Pages: 45-51
Related Report
Peer Reviewed
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[Presentation] 再生医療が拓く新しい医療2015
Author(s)
髙戸毅
Organizer
第101回日本消化器内視鏡学会関東地方会
Place of Presentation
シェーンバッハ・サボー、東京都
Year and Date
2015-12-12
Related Report
Invited
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