Role of cancer stroma on invasion and metastasis of oral squamous cell carcinoma
Project/Area Number |
26670861
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
|
Research Institution | Kanazawa University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 口腔扁平上皮癌 / 浸潤 / 転移 / 間質 / 線維芽細胞 / 血管新生 / 血管 / リンパ管 |
Outline of Final Research Achievements |
Using an orthotopic implantation mice model in which the invasion and metastasis of oral cancer can be reproduced, we investigated the inhibitory effects of cancer stromal fibroblast inhibitor (tranilast) and angiogenesis inhibitor (avastin) on invasion and metastasis. A highly invasive and metastatic human oral squamous cell carcinoma cell line, OSC-19, was implanted into the tongue of nude mice, and tranilast or avastin were administered to the mice after the implantation. The effects of each drug on cancer invasion and metastasis were investigated. Tumor size was significantly reduced. In the control group, the tumors showed grade 4C of mode of invasion, while in the groups treated with tranilast and avastin, grade 3 was observed, with an inhibitory effect on tumor invasion being observed. The rate of metastasis in the cervical lymph node was significantly decreased in the groups treated with tranilast and avastin.
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Report
(4 results)
Research Products
(25 results)