Development of vascular network construction method in vivo for enhancing tissue regeneration
| Project/Area Number |
26670863
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Nagoya University |
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Principal Investigator |
HIBI Hideharu 名古屋大学, 医学系研究科, 教授 (90345885)
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| Co-Investigator(Kenkyū-buntansha) |
山本 朗仁 徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (50244083)
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| Co-Investigator(Renkei-kenkyūsha) |
KATAGIRI Wataru 新潟大学, 医歯学系, 准教授 (10437030)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 移植・再生医療 / 再生医学 |
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| Outline of Final Research Achievements |
Cells release targeted factors into the culture environment. When the conditioned media derived from culturing bone marrow mesenchymal stem cells or dental pulp stem cells were applied in tissue defect models and organ disorder models, they were effective for regenerating tissues and alleviating disorders, and they followed vascular network construction. When the culture environment was set severely such as 1% oxygen concentration, genes related to angiogenesis expressed in cultured cells, those proteins in the conditioned media, tube formation and cell migration abilities were increased, it was effective for the vascular network construction. Applying the main factors in the conditioned media and also them excepting the main factors demonstrated the effectiveness of the factors for the vascular network construction. The research has opened the beginning of the vascular network construction method effective for tissue regeneration.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Secreted ectodomain of SIGLEC-9 and MCP-1 synergistically improve acute liver failure in rats by altering macrophage polarity2017
Author(s)
Ito T, Ishigami M, Matsushita Y, Hirata M, Matsubara K, Ishikawa T, Hibi H, Ueda M, Hirooka Y, Goto H, Yamamoto A
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 44043-44043
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Secreted factors from dental pulp stem cells improve glucose intolerance in streptozotocin-induced diabetic mice by increasing pancreatic β-cell function2015
Author(s)
Izumoto-Akita T, Tsunekawa S, Yamamoto A, Uenishi E, Ishikawa K, Ogata H, Iida A, Ikeniwa M, Hosokawa K, Niwa Y, Maekawa R, Yamauchi Y, Seino Y, Hamada Y, Hibi H, Arima H, Ueda M, Oiso Y
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Journal Title
BMJ Open Diabetes Research & Care
Volume: 3
Issue: 1
Pages: e000128-e000128
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] An experimental study on guided bone regeneration by using a polylactide-co-glycolide membrane-immobilized conditioned medium2015
Author(s)
Tsuchiya, S., Omori, M., Hara, K., Fujio, M., Ikeno, M., Hibi, H., Ueda, M.
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Journal Title
Journal of Oral and Maxillofacial Implants
Volume: 30
Related Report
Peer Reviewed
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