| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The aim of our study was to evaluate the usefulness and possibility of liquid biopsy for the patients with oral squamous cell carcinoma (OSCC). DNA was extracted from primary tumor tissues, plasma, and white blood cells in the patients with early or advanced OSCC, and then analyzed the mutations of 50 cancer-related genes by the next generation sequencer. As a result, tumor specific mutations in TP53 or PIK3CA were detected in primary tumor tissues from both early and advanced cases. However, each tumor specific mutation was also detected in plasma DNA from only advanced cases but not early case. Therefore, liquid biopsy may be useful for the patients with advanced OSCC.
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