Clinical application of liquid biopsy for oral cancer
| Project/Area Number |
26670866
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Ehime University |
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Principal Investigator |
Nakashiro Koichi 愛媛大学, 医学(系)研究科(研究院), 准教授 (90314880)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 口腔癌 / Liquid biopsy |
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| Outline of Final Research Achievements |
The aim of our study was to evaluate the usefulness and possibility of liquid biopsy for the patients with oral squamous cell carcinoma (OSCC). DNA was extracted from primary tumor tissues, plasma, and white blood cells in the patients with early or advanced OSCC, and then analyzed the mutations of 50 cancer-related genes by the next generation sequencer. As a result, tumor specific mutations in TP53 or PIK3CA were detected in primary tumor tissues from both early and advanced cases. However, each tumor specific mutation was also detected in plasma DNA from only advanced cases but not early case. Therefore, liquid biopsy may be useful for the patients with advanced OSCC.
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Report
(3 results)
Research Products
(3 results)
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[Journal Article] Prognostic significance of interleukin-8 and CD163-positive cell-infiltration in tumor tissues in patients with oral squamous cell carcinoma2014
Author(s)
Fujita Y, Okamoto M, Goda H, Tano T, Nakashiro K, Sugita A, Fujita T, Koido S, Homma S, Kawakami Y, Hamakawa H.
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Journal Title
PLoS ONE
Volume: 9
Issue: 12
Pages: e110378-e110378
DOI
Related Report
Peer Reviewed / Open Access
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