| Project/Area Number |
26670867
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kochi University |
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Principal Investigator |
KUNITO Jun 高知大学, 医学部附属病院, 医員 (90714452)
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| Co-Investigator(Kenkyū-buntansha) |
山本 哲也 高知大学, 教育研究部医療学系臨床医学部門, 教授 (00200824)
北村 直也 高知大学, 教育研究部医療学系臨床医学部門, 講師 (70351921)
笹部 衣里 高知大学, 教育研究部医療学系臨床医学部門, 講師 (40363288)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | エクソソーム / マイクロRNA / 口腔扁平上皮癌 / miRNA / microRNA |
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| Outline of Final Research Achievements |
It is difficult to diagnose the onset of oral squamous cell carcinoma as well as recurrence / metastasis, which is an important factor influencing prognosis. Establishment of more non-invasive and highly accurate diagnosis method than the conventional method is needed. Recently, it has been clarified that microRNA (miRNA) which is one type of non-coding RNA is involved in cancer onset, malignant transformation and resistance to treatment. Therefore, in this study, we focused miRNAs contained in serum exosomes of patients with oral squamous cell carcinoma (OSCC). We identified some miRNAs expressed specifically in OSCC cells and compared the expression level between oral cancer patients and non-cancer patients.
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