| Project/Area Number |
26670869
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
森山 雅文 九州大学, 歯学研究院, 助教 (20452774)
林田 淳之介 九州大学, 歯学研究院, 助教 (80432920)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | IgG4関連疾患 / 口唇腺生検 / 診断能 / 血清IgG4値 / DNAマイクロアレイ / TAM / 免疫抑制分子 / IgG4関連涙腺・唾液腺炎 / 唾液 / 診断 |
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| Outline of Final Research Achievements |
For the definitive diagnosis of IgG4-related disease (IgG4-RD), biopsies of local lesions are recommended so as to exclude other diseases. However, performing biopsies of underlying organs is technically difficult. In this study, we examined the diagnostic utility of labial salivary gland (LSG) biopsy as a less invasive procedure. Sixty-four patients with suspected IgG4-RD by clinical findings or high serum IgG4 underwent LSG biopsy. The sensitivity, specificity, and accuracy of LSG biopsy were 55.6%, 100.0%, and 68.8%, respectively. In the IgG4-RD patients witout lesions of salivary glands, the mean number of affected organs and serum IgG4 in the positive cases for LSG biopsy were significantly higher than in the negative cases. These results suggest that LSG biopsy combined with clinical findings, including serum IgG4 and number of affected organs, may contribute towards a diagnosis of IgG4-RD patients with affected underlying organs.
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