The diagnostic utility of salivary examination in IgG4-related disease

• Project/Area Number: 26670869
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: Nakamura Seiji 九州大学, 歯学研究院, 教授 (60189040)
• Co-Investigator(Kenkyū-buntansha): 森山 雅文 九州大学, 歯学研究院, 助教 (20452774) ; 林田 淳之介 九州大学, 歯学研究院, 助教 (80432920)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: IgG4関連疾患 / 口唇腺生検 / 診断能 / 血清IgG4値 / DNAマイクロアレイ / TAM / 免疫抑制分子 / IgG4関連涙腺・唾液腺炎 / 唾液 / 診断

Outline of Final Research Achievements

For the definitive diagnosis of IgG4-related disease (IgG4-RD), biopsies of local lesions are recommended so as to exclude other diseases. However, performing biopsies of underlying organs is technically difficult. In this study, we examined the diagnostic utility of labial salivary gland (LSG) biopsy as a less invasive procedure. Sixty-four patients with suspected IgG4-RD by clinical findings or high serum IgG4 underwent LSG biopsy. The sensitivity, specificity, and accuracy of LSG biopsy were 55.6%, 100.0%, and 68.8%, respectively. In the IgG4-RD patients witout lesions of salivary glands, the mean number of affected organs and serum IgG4 in the positive cases for LSG biopsy were significantly higher than in the negative cases. These results suggest that LSG biopsy combined with clinical findings, including serum IgG4 and number of affected organs, may contribute towards a diagnosis of IgG4-RD patients with affected underlying organs.

Research Products

• [Journal Article] Comparison of performance of the 2016 ACR-EULAR classification criteria for primary Sjogren’s syndrome with other sets of criteria in Japanese patients. (2017)
  • Author(s): Tsuboi H., Hagiwara S., Asashima H., Takahashi H., Harota T., Noma H., Umehara H., Kawakami A., Nakamura H., Sano H., Tsubota K., Ozawa Y., Takamura E., Saito I., Inoue H., Nakamura S., Moriyama M., Takeuchi T., Tanaka Y., Hirata S., Mimori T., Matsumoto I., Sumida T.
  • Journal Title: Ann. Rheum. Dis. Volume: 3 Issue: 12 Pages: 2016-210758
  • DOI: 10.1136/annrheumdis-2016-210758
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The diagnostic utility of labial salivary gland biopsy in IgG4-related disease (2016)
  • Author(s): Moriyama M, Ohta M, Furukawa S, Mikami Y, Tanaka A, Maehara T, Yamauchi M, Ishiguro N, Hayashida JN, Kawano S, Ohyama Y, Kiyoshima T, Nakamura S.
  • Journal Title: Mod Rheumatol Volume: 3 Issue: 5 Pages: 1-5
  • DOI: 10.3109/14397595.2016.1148225
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] DNA microarray analysis of submandibular glands in IgG4-related disease indicates a role for MARCO and other innate immune related proteins (2016)
  • Author(s): Ohta M, Moriyama M, Maehara T, Gion Y, Furukawa S, Tanaka A, Hayashida JN, Yamauchi M, Ishiguro N, Mikami Y, Tsuboi H, Iizuka-Koga M, Kawano S, Sato Y, Kiyoshima T, Sumida T, Nakamura S.
  • Journal Title: Medicine Volume: 97 Issue: 7 Pages: e2853-e2853
  • DOI: 10.1097/md.0000000000002853
  • NAID: 120007135530
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Saliva as a potential tool for diagnosis of dry mouth including Sjogren's syndrome. (2015)
  • Author(s): Ohyama K, Moriyama M et al.
  • Journal Title: Oral Dis Volume: 21(2) Issue: 2 Pages: 224-231
  • DOI: 10.1111/odi.12252
  • Peer Reviewed / Open Access
• [Journal Article] A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis. (2015)
  • Author(s): Ohta M, Moriyama M, Goto Y, Kawano S, Tanaka A, Maehara T, Furukawa S, J Hayashida JN, Kiyoshima T, Shimizu M, Arinobu Y, Nakamura S.
  • Journal Title: World J Surg Oncol Volume: 13 Issue: 1 Pages: 67-67
  • DOI: 10.1186/s12957-015-0459-z
  • Peer Reviewed / Open Access
• [Journal Article] Preferential M2 macrophages contribute to fibrosis in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz’s disease. (2014)
  • Author(s): Furukawa S, Moriyama M, Tanaka A, Maehara T, Tsuboi H, Iizuka M, Hayashida JN, Ohta M, Saeki T, Notohara K, Nakamura S.
  • Journal Title: Clinical Immnology Volume: 156 Issue: 1 Pages: 9-18
  • DOI: 10.1016/j.clim.2014.10.008
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] DNA microarray analysis of labial salivary glands in IgG4-related disease. Comparison with Sjögren’s syndrome. (2014)
  • Author(s): Tsuboi H, Nakai Y, Iizuka1 M, Asashima H, Hagiya C, Tsuzuki S, Hirota T, Miki H, Hagiwara S, Kondo Y, Tanaka A, Moriyama M, Matsumoto I, Nakamura S, Yoshihara T, Abe K, Sumida T.
  • Journal Title: Arthritis and Rheumatology Volume: 66 Issue: 10 Pages: 2892-2899
  • DOI: 10.1002/art.38748
  • Peer Reviewed / Open Access
• [Journal Article] Differences of Stimulated and Unstimulated Salivary Flow Rates in The Patients with Dry Mouth (2014)
  • Author(s): Jun-Nosuke Hayashida, Sakae Minami, Masafumi Moriyama, Takeshi Toyoshima, Shouichi Shinozaki, Akihiko Tanaka, Takashi Maehara, Seiji Nakamura
  • Journal Title: Journal of Oral and Maxillofacial Surgery, Medicine and Pathology Volume: 27 Issue: 1 Pages: 96-101
  • DOI: 10.1016/j.ajoms.2014.04.011
  • Peer Reviewed / Open Access
• [Journal Article] The diagnostic utility of biopsies from the submandibular and labial salivary glands in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz’s disease (2014)
  • Author(s): Moriyama M, Furukawa S, Kawano S, Goto Y, Kiyoshima T, Tanaka A, Maehara T, Hayashida JN, Ohta M, Nakamura S
  • Journal Title: Int J Oral Maxillofac Surg Volume: 43 Issue: 10 Pages: 1276-1281
  • DOI: 10.1016/j.ijom.2014.06.014
  • Peer Reviewed / Open Access
• [Journal Article] Clinical relevance of Kuttner tumour and IgG4-related dacryoadenitis and sialoadenitis. (2014)
  • Author(s): Furukawa S1, Moriyama M, Kawano S, Tanaka A, Maehara T, Hayashida JN, Goto Y, Kiyoshima T, Shiratsuchi H, Ohyama Y, Ohta M, Imabayashi Y, Nakamura S.
  • Journal Title: Oral Dis Volume: 21(2) Issue: 2 Pages: 257-62
  • DOI: 10.1111/odi.12259
  • Peer Reviewed / Open Access
• [Journal Article] T helper subsets in Sjogren’s syndrome and IgG4-related dacryoadenitis and sialoadenitis: A critical review. (2013)
  • Author(s): Moriyama M, et al.
  • Journal Title: J Autoimmun. Volume: in press Pages: 81-88
  • DOI: 10.1016/j.jaut.2013.07.007
  • Peer Reviewed / Open Access
• [Presentation] IgG4関連疾患の診断における口唇腺生検の有用性 (2015)
  • Author(s): 森山 雅文、太田 美穂、古川 祥子、三上 友理恵、山内 昌樹、石黒 乃理子、 川野 真太郎、大山 順子、清島 保、中村 誠司
  • Organizer: 第60回 日本口腔外科学会総会・学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-16
• [Presentation] IgG4 関連涙腺・唾液腺の疾患概念と免疫学的特徴 (2014)
  • Author(s): 森山 雅文、田中 昭彦、前原 隆、古川 祥子、中村 誠司
  • Organizer: 第24回 日本口腔内科学会・第27回 日本口腔診断学会 合同学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2014-09-20
  • Invited
• [Presentation] シェーグレン症候群とIgG4関連疾患の病態形成とT細胞サブセット (2014)
  • Author(s): 中村 誠司
  • Organizer: 第23回日本シェーグレン症候群学会学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-12
  • Invited
• [Presentation] IgG4 関連疾患の病態形成におけるTh 細胞および自然免疫細胞の関与 (2014)
  • Author(s): 森山 雅文、田中 昭彦、前原 隆、古川 祥子、太田 美穂、中村 誠司
  • Organizer: 第55回 日本神経学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2014-05-21
  • Invited
• [Book] 「IgG4-related disease」<Imaging> Salivary glands in Mikulicz’s disease (2014)
  • Author(s): Moriyama M, Nakamura S
  • Total Pages: 8
  • Publisher: Springer社
• [Book] 「臨床放射線 第59巻第8号 8月号」ミクリッツ病／IgG4関連疾患とシェーグレン症候群の新しい理解 (2014)
  • Author(s): 森山 雅文、中村 誠司
  • Total Pages: 11
  • Publisher: 金原出版株式会社