The diagnostic utility of salivary examination in IgG4-related disease
Project/Area Number |
26670869
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
森山 雅文 九州大学, 歯学研究院, 助教 (20452774)
林田 淳之介 九州大学, 歯学研究院, 助教 (80432920)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | IgG4関連疾患 / 口唇腺生検 / 診断能 / 血清IgG4値 / DNAマイクロアレイ / TAM / 免疫抑制分子 / IgG4関連涙腺・唾液腺炎 / 唾液 / 診断 |
Outline of Final Research Achievements |
For the definitive diagnosis of IgG4-related disease (IgG4-RD), biopsies of local lesions are recommended so as to exclude other diseases. However, performing biopsies of underlying organs is technically difficult. In this study, we examined the diagnostic utility of labial salivary gland (LSG) biopsy as a less invasive procedure. Sixty-four patients with suspected IgG4-RD by clinical findings or high serum IgG4 underwent LSG biopsy. The sensitivity, specificity, and accuracy of LSG biopsy were 55.6%, 100.0%, and 68.8%, respectively. In the IgG4-RD patients witout lesions of salivary glands, the mean number of affected organs and serum IgG4 in the positive cases for LSG biopsy were significantly higher than in the negative cases. These results suggest that LSG biopsy combined with clinical findings, including serum IgG4 and number of affected organs, may contribute towards a diagnosis of IgG4-RD patients with affected underlying organs.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Comparison of performance of the 2016 ACR-EULAR classification criteria for primary Sjogren’s syndrome with other sets of criteria in Japanese patients.2017
Author(s)
Tsuboi H., Hagiwara S., Asashima H., Takahashi H., Harota T., Noma H., Umehara H., Kawakami A., Nakamura H., Sano H., Tsubota K., Ozawa Y., Takamura E., Saito I., Inoue H., Nakamura S., Moriyama M., Takeuchi T., Tanaka Y., Hirata S., Mimori T., Matsumoto I., Sumida T.
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Journal Title
Ann. Rheum. Dis.
Volume: 3
Issue: 12
Pages: 2016-210758
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The diagnostic utility of labial salivary gland biopsy in IgG4-related disease2016
Author(s)
Moriyama M, Ohta M, Furukawa S, Mikami Y, Tanaka A, Maehara T, Yamauchi M, Ishiguro N, Hayashida JN, Kawano S, Ohyama Y, Kiyoshima T, Nakamura S.
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Journal Title
Mod Rheumatol
Volume: 3
Issue: 5
Pages: 1-5
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] DNA microarray analysis of submandibular glands in IgG4-related disease indicates a role for MARCO and other innate immune related proteins2016
Author(s)
Ohta M, Moriyama M, Maehara T, Gion Y, Furukawa S, Tanaka A, Hayashida JN, Yamauchi M, Ishiguro N, Mikami Y, Tsuboi H, Iizuka-Koga M, Kawano S, Sato Y, Kiyoshima T, Sumida T, Nakamura S.
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Journal Title
Medicine
Volume: 97
Issue: 7
Pages: e2853-e2853
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis.2015
Author(s)
Ohta M, Moriyama M, Goto Y, Kawano S, Tanaka A, Maehara T, Furukawa S, J Hayashida JN, Kiyoshima T, Shimizu M, Arinobu Y, Nakamura S.
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Journal Title
World J Surg Oncol
Volume: 13
Issue: 1
Pages: 67-67
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Preferential M2 macrophages contribute to fibrosis in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz’s disease.2014
Author(s)
Furukawa S, Moriyama M, Tanaka A, Maehara T, Tsuboi H, Iizuka M, Hayashida JN, Ohta M, Saeki T, Notohara K, Nakamura S.
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Journal Title
Clinical Immnology
Volume: 156
Issue: 1
Pages: 9-18
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] DNA microarray analysis of labial salivary glands in IgG4-related disease. Comparison with Sjögren’s syndrome.2014
Author(s)
Tsuboi H, Nakai Y, Iizuka1 M, Asashima H, Hagiya C, Tsuzuki S, Hirota T, Miki H, Hagiwara S, Kondo Y, Tanaka A, Moriyama M, Matsumoto I, Nakamura S, Yoshihara T, Abe K, Sumida T.
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Journal Title
Arthritis and Rheumatology
Volume: 66
Issue: 10
Pages: 2892-2899
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The diagnostic utility of biopsies from the submandibular and labial salivary glands in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz’s disease2014
Author(s)
Moriyama M, Furukawa S, Kawano S, Goto Y, Kiyoshima T, Tanaka A, Maehara T, Hayashida JN, Ohta M, Nakamura S
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Journal Title
Int J Oral Maxillofac Surg
Volume: 43
Issue: 10
Pages: 1276-1281
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical relevance of Kuttner tumour and IgG4-related dacryoadenitis and sialoadenitis.2014
Author(s)
Furukawa S1, Moriyama M, Kawano S, Tanaka A, Maehara T, Hayashida JN, Goto Y, Kiyoshima T, Shiratsuchi H, Ohyama Y, Ohta M, Imabayashi Y, Nakamura S.
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Journal Title
Oral Dis
Volume: 21(2)
Issue: 2
Pages: 257-62
DOI
Related Report
Peer Reviewed / Open Access
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