Wound Healing via utilizing thermosensitivity

• Project/Area Number: 26670870
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: Kido Mizuho 九州大学, 歯学研究科(研究院), 准教授 (60253457)
• Co-Investigator(Kenkyū-buntansha): Ohyama Yukiko 九州大学, 大学院歯学研究院, 助教 (70294957)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 口腔粘膜 / イオンチャネル / 創傷治癒 / TRPチャネル / 上皮間葉転換 / 口腔上皮 / 温度感受性 / マウス

Outline of Final Research Achievements

Oral mucosa is exposed by various stimuli including thermal, mechanical or chemical stimuli in food and drink. Because of that, it is susceptible to injure but is known to heal faster compared with the skin. As the temperature in the oral cavity is higher than on the skin, we explore the effect of thermosensitive ion channel, TRPV3 (transient receptor potential vanilloid channel) on the wound healing processes. Since we found delayed wound healing in the TRPV3 gene deleted mice, TRPV3 is suggested to be important molecule in the oral wound healing processes.

Research Products

• [Journal Article] The thermosensitive TRPV3 channel contributes to rapid wound healing in oral epithelia (2015)
  • Author(s): Aijima R, Wang B, Takao T, Mihara H, Kashio M, Ohsaki Y, Zhang JQ, Mizuno A, Suzuki M, Yamashita Y, Masuko S, Goto M, Tominaga M, Kido MA
  • Journal Title: The FASEB Journal Volume: 29 Issue: 1 Pages: 182-192
  • DOI: 10.1096/fj.14-251314
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 口腔創治癒過程における上皮間葉転換分子の経時的発現変化 (2015)
  • Author(s): 合島怜央奈、木附智子、吉本怜子、大崎康吉、張 旌旗、檀上 敦、山下佳雄、村田 祐造、城戸瑞穂
  • Organizer: 第９回三叉神経領域の感覚ー運動統合統合機構研究会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-28
• [Presentation] Temperature sensitive TRP channels in Oral Epithelial Barrier (2015)
  • Author(s): Mizuho A Kido, Tomoko Kitsuki, Reona Aijima, Reiko Yoshimoto, Jing-Qi Zhang, Yasuyoshi Ohsaki
  • Organizer: 13th International symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (YR Umami Forum 2015)
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2015-11-03
  • Int'l Joint Research
• [Presentation] 温度感受性 TRPチャネルを介した口腔粘膜の創傷治癒制御 (2015)
  • Author(s): 合島怜央奈、王 冰、高尾知佳、三原 弘、加塩麻紀子、 大崎康吉、張 旌旗、木附智子、村田 祐造、富永真琴、城戸瑞穂
  • Organizer: 生体ホメオスタシスのgatewayとしての上皮膜輸送マイクロホメオスタシス機構
  • Place of Presentation: 自然科学研究機構 生理学研究所
  • Year and Date: 2015-09-15
• [Presentation] Oral mucosal barrier via thermosensitive TRP channels (2015)
  • Author(s): Reona Aijima, Tomoko Kitsuki , Bing Wang, Tomoka Takao, Hiroshi Mihara, Makiko Kashio, Reiko Yoshimoto, Yasuyoshi Ohsaki, Jing-Qi Zhang, Makoto Tominaga, Mizuho A. Kido
  • Organizer: Third TRP meeting Leuven
  • Place of Presentation: Leuven, Bergium
  • Year and Date: 2015-09-15
  • Int'l Joint Research
• [Presentation] 口腔粘膜におけるTRPV3チャネルのEGFRシグナルを介した速やかな創傷治癒への関与 (2015)
  • Author(s): 合島怜央奈、木附智子、王 冰、高尾知佳、三原弘、加塩麻紀子、大崎康吉、張 旌旗、富永真琴、城戸瑞穂
  • Organizer: 第120回日本解剖学会総会･全国学術集会・第92回日本生理学会大会（合同大会）
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] 口腔粘膜の防禦に関わる温度感受性TRPチャネル. シンポジウム「温度感受性TRPチャネルの発現・構造機能」 (2015)
  • Author(s): 城戸瑞穂
  • Organizer: 第120回日本解剖学会総会･全国学術集会・第92回日本生理学会大会（合同大会）
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] 温度感受性TRPチャネル活性化による新しい口腔上皮治癒機構の解明. (2014)
  • Author(s): 口腔粘膜におけるTRPV3チャネルを介した創傷治癒制御
  • Organizer: 第56回歯科基礎医学会学術大会・総会
  • Place of Presentation: 福岡
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] The thermosensitive TRPV3 channel contributes to rapid wound healing in oral epithelia. (2014)
  • Author(s): 13.Aijima R, Yamashita Y, Danjo A, Kido MA, Goto M.
  • Organizer: American Association of Oral and Maxillofacial Surgeons 96th Annual Meeting
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2014-09-08 – 2014-09-13
• [Presentation] 口腔粘膜におけるTRPV3チャネルを介した創傷治癒制御 (2014)
  • Author(s): 合島 怜央奈、王冰、高尾知佳、三原弘、加塩麻紀子、大崎康吉、張旌旗、水野敦子、鈴木誠、富永真琴、城戸瑞穂
  • Organizer: 第10回TRPチャネル研究会
  • Place of Presentation: 岡崎
  • Year and Date: 2014-06-05 – 2014-06-06