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Functional miRNA promotes the bone regeneration with rhBMP2 and ADCs

Research Project

Project/Area Number 26670871
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionNagasaki University

Principal Investigator

TAJIMA Nobutaka  長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (00447492)

Co-Investigator(Kenkyū-buntansha) ASAHINA Izumi  長崎大学, 医歯薬学総合研究科(歯学系), 教授 (30221039)
SUMITA Yoshinori  長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (50456654)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords骨再生 / 脂肪由来細胞 / microRNA / BMP / miRNA
Outline of Final Research Achievements

Direct implantation of freshly isolated adipose-derived cells (ADC) with minimal amount of rhBMP2 to the mouse cranium were performed to assess the effectiveness of administration of functional miRNA in vivo. On the other hand, mouse adipose mesenchymal stem cells (AD-MSC) were exposed to rhBMP2 for osteoblastic induction in culture to search the candidates of miRNAs. As a result, when a certain miRNA, which were chosen in vitro assay, were transplanted with ADC and minimal amount of BMP2, we found this miRNA can accelerate the new bone formation. At present, we are doing further experiments to investigate the function of this miRNA in detail.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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