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A novel design of metabolic target therapy in oral cancer cells

Research Project

Project/Area Number 26670872
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionSapporo Medical University

Principal Investigator

Ogi Kazuhiro  札幌医科大学, 医学部, 講師 (40433114)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords糖代謝阻害薬 / グルコーストランスポーター / 糖代謝阻害剤 / GLUT-1 / 糖代謝 / 放射線耐性 / DNA修復能 / がん微小環境 / 代謝調節 / 放射線治療
Outline of Final Research Achievements

2 - DG (2 - deoxy - D - glucose), a glucose metabolism inhibitor takes into tumor cells, but the amount of uptakes are depending on the phenotype of tumor cells. In our study, we established mice xenograft models with oral squamous cell carcinoma cell line , and we examined the antitumor effect by the combination of radiotherapy with 2-DG. As a result, in the group of the combination of radiotherapy with 2-DG, there is a significant tumor growth suppression compared with the control group and 2-DG alone. Our study suggested that 2-DG has synergistic effects when combined with radiotherapy, which might lead to the design of an effective metabolic target therapy.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Low-grade mucoepidermoid carcinoma with regional lymph node metastasis: A case report and genetic review of criteria for grading2016

    • Author(s)
      中垣貴文, 荻 和弘
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: 28 Issue: 2 Pages: 189-192

    • DOI

      10.1016/j.ajoms.2015.08.006

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] がん微小環境において解糖系阻害薬を併用した放射線増感効果に関する研究.2016

    • Author(s)
      荻 和弘
    • Organizer
      第61回日本口腔外科学会総会・学術大会
    • Place of Presentation
      幕張メッセ国際会議場・国際展示場(千葉県千葉市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] DNA double-strand breaks in hypoxic but not in normoxicconditions determine different radiosensitivity of tumors2015

    • Author(s)
      荻 和弘
    • Organizer
      アメリカ癌学会
    • Place of Presentation
      米国・フィラデルフィア
    • Year and Date
      2015-04-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] DNA double strand breaks in hypoxic but not in normoxic conditions determine different radiosensitivity of tumors in oral squamous cell carcinoma2015

    • Author(s)
      荻 和弘
    • Organizer
      アメリカ癌学会
    • Place of Presentation
      米国・フィラデルフィア
    • Year and Date
      2015-04-21
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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