| Project/Area Number |
26670877
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University (2015)
Aichi Cancer Center Research Institute (2014) |
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Principal Investigator |
Fujii Makiko 広島大学, 医歯薬保健学研究院(歯), 教授 (70406031)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 口腔扁平上皮癌 / Hippoシグナル / YAP / Hippo / 口腔扁平上皮癌細胞 / TGF-beta / CTGF |
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| Outline of Final Research Achievements |
Based on our previous findings in malignant mesothelioma cells, we have examined the role of CTGF in other cancer cell lines including squamous cell carcinoma and osteosarcoma. Expression of CTGF was detected mainly in osteosarcoma cells, but not in squamous cell carcinomas. Knockdown of CTGF suppressed the growth of only in osteosarcoma cells, suggesting that CTGF plays critical role in the growth of osateosarcoma cells, but not in squamous cell carcinomas. These data suggested that Hippo-YAP-CTGF pathway plays an important role in the growth of malignant tumor originated from non-epithelial cells.
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