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Restoration of tooth enamel by biomineralization with oyster shell nano-powder and enamel matrix proteins

Research Project

Project/Area Number 26670885
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Orthodontics/Pediatric dentistry
Research InstitutionHiroshima University

Principal Investigator

Tanimoto Kotaro  広島大学, 医歯薬保健学研究院, 教授 (20322240)

Co-Investigator(Kenkyū-buntansha) KUNIMATSU Ryo  広島大学, 大学院医歯薬保健学研究院, 助教 (40580915)
HIROSE Naoto  広島大学, 大学院医歯薬保健学研究院, 助教 (50611935)
KEISUKE Sumi  広島大学, 大学院医歯薬保健学研究院, 助教 (00707078)
YOSHIMI Yuki  広島大学, 大学病院, 歯科診療医 (50707081)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsバイオミネラリゼーション
Outline of Final Research Achievements

Recombinant human amelogenin formed nanosphere in solution at neutral pH. The surface roughness of tooth enamel surface was decreased significantly by the biomineralization treatment with amelogenin. Artificial plaque was removed effectively by the treatment with oyster shell nano-powder, whereas no obvious biomineralization effects were shown. A method to maintain oyster shell nano-powder onto enamel surface is considered to be necessary, and a further investigation to find better condition for biomineralization is desired.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] 広島大学病院矯正歯科におけるエナメル質形成不全永久歯の発現実態に関する臨床調査2014

    • Author(s)
      沖 奈苗, 本川 雅英, 國松 亮, 廣瀬 尚人, 吉見 友希, 谷本 幸太郎
    • Journal Title

      Orthodontic Waves-Japanese Edition

      Volume: 73 Pages: 137-142

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 矯正歯科治療におけるカリエスリスクへの挑戦ー遺伝要因のスクリニングとバイオミネラリゼーション治療2016

    • Author(s)
      谷本幸太郎
    • Organizer
      広島矯正歯科医会学術講演会
    • Place of Presentation
      広島市
    • Year and Date
      2016-03-14
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] より細い粒子化した牡蠣殻ナノパウダーの歯面清掃効果およびエナメル質修復効果の検討2015

    • Author(s)
      鷲見圭輔, 國松 亮, 広瀬尚人, 吉見友希, 粟田哲也, 阿部崇晴, 沖田紗季, 中尾裕子, 谷本幸太郎
    • Organizer
      第74回日本矯正歯科学会大会
    • Place of Presentation
      福岡市
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 牡蠣殻ナノパウダーの歯面清掃効果およびエナメル質修復効果の検討2014

    • Author(s)
      國松 亮, 鷲見 圭輔, 麻川 由起 , 廣瀬 尚人 , 光吉 智美 , 吉見 友希, 郡司 秀美, 谷本幸太郎
    • Organizer
      第73回日本矯正歯科学会大会
    • Place of Presentation
      千葉市
    • Year and Date
      2014-10-20 – 2014-10-22
    • Related Report
      2014 Research-status Report
  • [Presentation] アメロゲニンの骨芽細胞代謝調節機構への影響―エナメル蛋白由来ペプチドを用いた骨再生療法への展開―2014

    • Author(s)
      粟田 哲也, 國松 亮, 吉見 友希, 廣瀬 尚人, 小島俊逸, 加来真人, 平田 伊佐雄, 加藤 功一, 丹根 一夫, 谷本 幸太郎
    • Organizer
      第38回日本口蓋裂学会
    • Place of Presentation
      札幌市
    • Year and Date
      2014-05-29 – 2014-05-30
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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