Identification for "tooth genes" in neural crest derived mesenchmal cells
| Project/Area Number |
26670886
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 歯 / 再生医学 / 細胞分化 / 間葉細胞 / 細胞凝集 / 歯原性上皮細胞 |
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| Outline of Final Research Achievements |
Tooth morphogenesis is initiated by epithelial-mesenchymal interaction, and the neural crest-derived mesenchymal cells play an important role in tooth development. In this study, we identified two genes, which were specifically expressed in mesenchymal cells in tooth development. These genes were strongly expressed in E13-E16 tooth germ, which is the morphogenesis stage of tooth development, and the expression level was declined in the differentiation stage. Furthermore, we identified that dental mesenchymal cells transfected with identified genes were critical for epithelial-mesenchymal interaction. These results suggest that the identified genes may play important roles in tooth morphogenesis.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Nephronectin plays critical roles in Sox2 expression and proliferation in dental epithelial stem cells via EGF-like repeat domains2017
Author(s)
Chieko Arai, Keigo Yoshizaki, Kanako Miyazaki, Kan Saito, Aya Yamada, Xue Han, Keita Funada, Emiko Fukumoto, Naoto Haruyama, Tsutomu Iwamoto, Ichiro Takahashi, Satoshi Fukumoto
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Journal Title
Scientific Reports
Volume: 27
Pages: 45181-45181
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Plakophilin-1, a novel Wnt signaling regulator, is critical for tooth development and ameloblast differentiation2016
Author(s)
Miyazaki K, Yoshizaki K, Arai C, Yamada A, Saito K, Ishikawa M, Xue H, Funada K, Haruyama N, Yamada Y, Fukumoto S, Takahashi I
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Journal Title
Plos One
Volume: 11
Issue: 3
Pages: 0152206-0152206
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Connexin 43 is necessary for salivary gland branching morphogenesis and FGF10-induced ERK1/2 phosphorylation2016
Author(s)
Yamada A, Futagi M, Fukumoto E, Saito K, Yoshizaki K, Ishikawa M, Arakaki M, Hino R, Sugawara Y, Ishikawa M, Naruse M, Miyazaki K, Nakamura T, Fukumoto S.
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Journal Title
The Journal of Biological Chemistry
Volume: 291
Issue: 2
Pages: 904-912
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2-induced Smad1/5/8 phosphorylation2016
Author(s)
Liu J, Saito K*, Maruya Y, Nakamura T, Yamada A, Fukumoto E, Ishikawa M, Iwamoto T, Miyazaki K, Yoshizaki K, Ge L, Fukumoto S
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Journal Title
Scientific reports
Volume: 6
Issue: 1
Pages: 23670-23670
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Interaction between Fibronectin and β1 Integrin is Essential for Tooth Development.2015
Author(s)
Saito, K., Fukumoto, E., Yamada, A., Yuasa, K., Yoshizaki, K., Iwamoto, T., Saito, M., Nakamura, T., and Fukumoto, S.
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Journal Title
PLOS one
Volume: 10(4)
Issue: 4
Pages: 1-12
DOI
NAID
Related Report
Peer Reviewed / Open Access
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