| Project/Area Number |
26670886
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 歯 / 再生医学 / 細胞分化 / 間葉細胞 / 細胞凝集 / 歯原性上皮細胞 |
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| Outline of Final Research Achievements |
Tooth morphogenesis is initiated by epithelial-mesenchymal interaction, and the neural crest-derived mesenchymal cells play an important role in tooth development. In this study, we identified two genes, which were specifically expressed in mesenchymal cells in tooth development. These genes were strongly expressed in E13-E16 tooth germ, which is the morphogenesis stage of tooth development, and the expression level was declined in the differentiation stage. Furthermore, we identified that dental mesenchymal cells transfected with identified genes were critical for epithelial-mesenchymal interaction. These results suggest that the identified genes may play important roles in tooth morphogenesis.
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