| Project/Area Number |
26670910
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | Iwate Biotechnology Research Center |
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Principal Investigator |
Yano Akira 公益財団法人岩手生物工学研究センター, 生物資源研究部, 研究部長 (50312286)
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| Co-Investigator(Kenkyū-buntansha) |
YASHIRODA Yoko 国立開発法人理化学研究所, 吉田化学遺伝学研究室, 専任研究員 (60360658)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 多価不飽和脂肪酸 / ステアリドン酸 / アムホテリシンB / フルコナゾール / Candida albicans / Fatty acids / Stearidonic acids / Ricinoleic acids / Amphotericin B / Biofilm |
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| Outline of Final Research Achievements |
We investigated fungal growth inhibitory activity of several extracts of foods, especially in the northern Tohoku region. The fat-soluble component of cereals and marine products (Hoya, etc.) showed strong inhibitory activity of hyphal formation. We identified these active ingredients and examined their effects on anti-fungal agents. The synergistic effects of fungicides and food ingredients were studied for elucidate their mechanism of action. As a result, polyunsaturated fatty acids, particularly stearidonic acid has antiproliferative activity of a fungal, it has been found to act synergistically with amphotericin B. As a result of chemical genomics analysis with the budding yeast, it is suggested that stearidonic acid inhibits intracellular trafficking pathways. The stearidonic acid might affect the functions of membrane proteins including components of membrane traffic, and strongly inhibit the growth of fungi.
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