Comparative study of elderly twin data from Japanese and Northern European countries: building a healthy and logevity society

• Project/Area Number: 26671010
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Gerontological nursing
• Research Institution: Osaka University
• Principal Investigator: Honda Chika 大阪大学, 医学系研究科, 特任准教授(常勤) (40625498)
• Co-Investigator(Kenkyū-buntansha): 冨澤 理恵 大阪大学, 医学系研究科, 特任講師(常勤) (20584551) ; 乾 富士男 畿央大学, 健康科学部, 准教授 (80469551)
• Co-Investigator(Renkei-kenkyūsha): HAYAKAWA Kazuo 三重県立看護大学, 看護学部, 教授 (70142594)
• Research Collaborator: KAPRIO Jaakko ヘルシンキ大学, 医学部, Professor ; SILVENTOINEN Karri ヘルシンキ大学, 社会学部, Senior Lecturer
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 双生児研究 / 公衆衛生学 / 疫学 / 公衆衛生 / 地域保健 / 国際比較

Outline of Final Research Achievements

Twin research is an ideal approach to understand the genetic and environmental influence on human phenotypes including health. Particularly, it enables estimation of heritability to understand the relative proportion of genetic and environmental influences. The current study investigated Japanese adult twins on physical and psychological health, and then compared it with twins from Finland and other countries. It showed how genetic and environmental influences varied as age changes.

Research Products

• [Int'l Joint Research] ヘルシンキ大学(フィンランド)
• [Int'l Joint Research] ヘルシンキ大学(フィンランド)
• [Journal Article] Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994 (2016)
  • Author(s): Jelenkovic A, Hur YM, Sund R, Yokoyama Y, Siribaddana SH, Hotopf M, Sumathipala A, Rijsdijk F, Tan Q, Zhang D, Pang Z, Aaltonen S, Heikkilä K, Öncel SY, Aliev F, Rebato E, Tarnoki AD, Tarnoki DL, Christensen K, Skytthe A, Kyvik KO, Silberg JL, Eaves LJ, Maes HH, Cutler TL, Hopper JL, et al.
  • Journal Title: Elife Volume: 5 Pages: 1-14
  • DOI: 10.7554/elife.20320
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study (2016)
  • Author(s): Silventoinen K, Jelenkovic A, Sund R, Hur YM, Yokoyama Y, et al.
  • Journal Title: Am J Clin Nutr Volume: 104(2) Issue: 2 Pages: 371-379
  • DOI: 10.3945/ajcn.116.130252
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A longitudinal twin study on Tojikomori and depressive symptoms in Japanese elderly (2015)
  • Author(s): Fujio Inui, Chika Honda, Kenji Kato, Rie Tomizawa, Reiko Nishihara, Kazuo Hayakawa
  • Journal Title: Psychogeriatrics Volume: Early View Issue: 4 Pages: 255-262
  • DOI: 10.1111/psyg.12157
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits (2015)
  • Author(s): Karri Silventoinen, Aline Jelenkovic, Reijo Sund, et al.
  • Journal Title: Twin Research and Human Genetics Volume: 18(4) Issue: 4 Pages: 348-360
  • DOI: 10.1017/thg.2015.29
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project. (2015)
  • Author(s): Aline Jelenkovic, Yoshie Yokoyama, Reijo Sund, Chika Honda et al.
  • Journal Title: Twin Research and Human Genetics Volume: 18 Issue: 5 Pages: 557-570
  • DOI: 10.1017/thg.2015.57
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The CODAtwins project: the cohort description of COllaborative project of Development of Anthropometrical measures in Twins to study macro-environmental variation in genetic and environmental effects on anthropometric traits (2015)
  • Author(s): Karri Silventoinen, Aline Jelenkovic, Reijo Sund, Chika Honda, et al.
  • Journal Title: Twin Research and Human Genetics Volume: TBA
  • Peer Reviewed
• [Journal Article] 多胎児の予後 学童期以降の問題点ー中高年齢の双生児研究からみた長期予後：環境の健康影響のエピジェネティクス研究 (2015)
  • Author(s): 早川和夫、本多智佳
  • Journal Title: 周産期医学 Volume: 45 Pages: 105-108
• [Journal Article] Genetic and environmental influences on motor function: a magnetoencephalographic study of twins. (2014)
  • Author(s): Araki T, Hirata M, Sugata H, Yanagisawa T, Onishi M, Watanabe Y, Omura K, Honda C, Hayakawa K and Yorifuji S
  • Journal Title: Front. Hum. Neurosci. Volume: 8 Pages: 455-455
  • DOI: 10.3389/fnhum.2014.00455
• [Presentation] 成人双生児における遺伝要因を調整した生活習慣と血清脂質との関連分析 (2015)
  • Author(s): 田中健太郎、本多智佳, 他
  • Organizer: 第２９回日本双生児研究学会学術講演会
  • Place of Presentation: 金沢市、石川県
  • Year and Date: 2015-01-24
• [Presentation] 双生児法を用いた言語活動時の脳機能における遺伝的影響の検討 (2014)
  • Author(s): 荒木俊彦、平田雅之、柳澤琢史、菅田陽怜、大西舞、谷山歩、大村佳代子、本多智佳、早川和男、依藤史郎
  • Organizer: 第４４回日本臨床神経生理学会
  • Place of Presentation: 福岡県
  • Year and Date: 2014-11-20
• [Presentation] Association between height and metabolic risk factors of cardio-vascular diseases in Japanese and Finnish twins (2014)
  • Author(s): Karri Silventoinen, Chika Honda, Soshiro Ogata, Kayoko Omura, Taina Rantanen, Anne Viljanen, Jaakko Kaprio, Kazuo Hayakawa and Osaka Twin Research Group
  • Organizer: The 15 th Congress of the International Society for Twin Studies
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2014-11-16 – 2014-11-19
• [Presentation] Relationship between metabolic syndrome and Breslow's seven health practice index without genetic factors: a study of Japanese adult twins (2014)
  • Author(s): Kentaro Tanaka, Chika Honda, Haruka Tanaka, et al.
  • Organizer: The 15 th Congress of the International Society for Twin Studies
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2014-11-16 – 2014-11-19