Evaluation of mouse model of developmental disorders by using body ownership illusion task
| Project/Area Number |
26700012
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Cognitive science
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| Research Institution | National Rehabilitation Center for Persons with Disabilities |
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Principal Investigator |
Wada Makoto 国立障害者リハビリテーションセンター(研究所), 研究所 脳機能系障害研究部, 研究室長 (20407331)
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| Research Collaborator |
FURUICHI Teiichi
KANSAKU Kenji
SHINODA Yo
SANO Yoshitake
IDE Masakazu
ATSUMI Takeshi
NAWA Taemi
KUME Naoko
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Keywords | 多感覚統合 / 身体性 / マウス / 自閉症モデル動物 / 免疫染色 / 認知科学 / 実験系心理学 / 神経科学 / 脳・神経 / 脳神経疾患 |
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| Outline of Final Research Achievements |
In individuals with autism spectrum disorder (ASD), they have impairment in body representations and it may cause deficits in motor behaviors and viewpoints. In typically developing individuals, when someone’s hand and a fake hand (i.e., rubber hand) are stroking synchronously, the participant feels the fake hand becomes her/his own hand. In contrast, individuals with ASD feel this illusion much weaker. We found even mice may feel such kind of body ownership illusions. A fake tail and a tail were synchronously stroking more than one minute. When the fake tail was grasped, a mouse responded as if his actual tail was grasped (rubber tail response). We examined whether the rubber tail response is intact or not in autism model mice, and found that response rates were not significantly different between test and control conditions in Caps2 KO mice, and decreased c-Fos expressions in the posterior parietal cortex might be related. Multisensory integration might be impaired in the KO mice.
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Report
(4 results)
Research Products
(28 results)
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[Presentation] マウスのラバーテイル課題2014
Author(s)
和田真,大良宏樹,高野弘二,神作憲司
Organizer
第6回多感覚研究会
Place of Presentation
広島大学, 広島
Year and Date
2014-11-12 – 2014-11-13
Related Report
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