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Evaluation of mouse model of developmental disorders by using body ownership illusion task

Research Project

Project/Area Number 26700012
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Cognitive science
Research InstitutionNational Rehabilitation Center for Persons with Disabilities

Principal Investigator

Wada Makoto  国立障害者リハビリテーションセンター(研究所), 研究所 脳機能系障害研究部, 研究室長 (20407331)

Research Collaborator FURUICHI Teiichi  
KANSAKU Kenji  
SHINODA Yo  
SANO Yoshitake  
IDE Masakazu  
ATSUMI Takeshi  
NAWA Taemi  
KUME Naoko  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Keywords多感覚統合 / 身体性 / マウス / 自閉症モデル動物 / 免疫染色 / 認知科学 / 実験系心理学 / 神経科学 / 脳・神経 / 脳神経疾患
Outline of Final Research Achievements

In individuals with autism spectrum disorder (ASD), they have impairment in body representations and it may cause deficits in motor behaviors and viewpoints. In typically developing individuals, when someone’s hand and a fake hand (i.e., rubber hand) are stroking synchronously, the participant feels the fake hand becomes her/his own hand. In contrast, individuals with ASD feel this illusion much weaker. We found even mice may feel such kind of body ownership illusions. A fake tail and a tail were synchronously stroking more than one minute. When the fake tail was grasped, a mouse responded as if his actual tail was grasped (rubber tail response). We examined whether the rubber tail response is intact or not in autism model mice, and found that response rates were not significantly different between test and control conditions in Caps2 KO mice, and decreased c-Fos expressions in the posterior parietal cortex might be related. Multisensory integration might be impaired in the KO mice.

Report

(4 results)
  • 2017 Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (28 results)

All 2017 2016 2015 2014 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 4 results,  Open Access: 3 results) Presentation (21 results) (of which Int'l Joint Research: 2 results,  Invited: 7 results) Remarks (3 results)

  • [Journal Article] Salivary oxytocin concentration associates with the subjective feeling of body ownership during the rubber hand illusion.2017

    • Author(s)
      Ide M, Wada M
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 11 Pages: 116-116

    • DOI

      10.3389/fnhum.2017.00166

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The rubber tail illusion as evidence of body ownership in mice.2016

    • Author(s)
      Wada, M., Takano, K., Ora, H., Ide, M., Kansaku, K.
    • Journal Title

      The Journal of Neuroscience

      Volume: 36 Issue: 43 Pages: 11133-11137

    • DOI

      10.1523/jneurosci.3006-15.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Periodic visuotactile stimulation slowly enhances the rubber hand illusion in individuals with high autistic traits.2016

    • Author(s)
      Ide M, Wada M
    • Journal Title

      Frontiers in Integrative Neuroscience

      Volume: 10 Pages: 21-21

    • DOI

      10.3389/fnint.2016.00021

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Rubber hand presentation modulates visuotactile interference effect especially in persons with high autistic traits.2016

    • Author(s)
      Wada M, Ide M.
    • Journal Title

      Experimental Brain Research

      Volume: 234 Issue: 1 Pages: 51-65

    • DOI

      10.1007/s00221-015-4429-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Comparison between response in real tail grasping and rubber tail illusion in mice.2017

    • Author(s)
      Wada M, Ide M, Takano T, Ora H, Kansaku K
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松
    • Related Report
      2016 Annual Research Report
  • [Presentation] C-Fos and Arc expression during a rubber tail task in mice: an initial study.2016

    • Author(s)
      Wada, M., Ide, M., Ora, H., & Kansaku, K.
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Associations between salivary oxytocin concentration and subjective feeling during rubber hand illusion.2016

    • Author(s)
      Ide, M., & Wada, M.
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Multisensory processing and body image in human and animals2016

    • Author(s)
      Wada, M.
    • Organizer
      International Symposium toward the Future of Advanced Researches in Shizuoka University
    • Place of Presentation
      静岡大学 浜松キャンパス
    • Year and Date
      2016-03-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒトと自閉症モデル動物の感覚間統合と感覚過敏の研究紹介2016

    • Author(s)
      井手正和, 和田 真
    • Organizer
      感覚とその発達メカニズムに関する研究交流会
    • Place of Presentation
      京都大学こころの未来研究センター
    • Year and Date
      2016-02-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] A rubber tail task in Ca-dependent activator protein for secretion (CAPS) 2 knockout mice.2016

    • Author(s)
      Wada M, Ide M, Atsumi T, Yagishita K, Katakai M, Shinoda Y, Furuichi T, Kansaku K
    • Organizer
      The 46th annual meeting of Society for Neuroscience
    • Place of Presentation
      San Diego
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Do mice discriminate biological motion?2016

    • Author(s)
      Atsumi T, Ide M, Wada M
    • Organizer
      日本動物心理学会第76回大会
    • Place of Presentation
      北海道大学
    • Related Report
      2016 Annual Research Report
  • [Presentation] A rubber tail task in CAPS2 KO mice: second report.2016

    • Author(s)
      Wada M, Ide M, Atsumi T, Yagishita K, Katakai M, Shinoda Y, Furuichi T, Kansaku K
    • Organizer
      日本動物心理学会第76回大会
    • Place of Presentation
      北海道大学
    • Related Report
      2016 Annual Research Report
  • [Presentation] 発達障害者における感覚情報処理と身体像の特徴2016

    • Author(s)
      和田真
    • Organizer
      第二回脳情報学セミナー
    • Place of Presentation
      静岡大学
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Body representation based on visuotactile integration in human and animal2015

    • Author(s)
      Ide, M, Wada, M.
    • Organizer
      京都大学理学研究科生物学専攻心理セミナー
    • Place of Presentation
      京都大学霊長類研究所
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 多感覚の情報処理と身体像-自閉傾向と比較認知からの検討-2015

    • Author(s)
      和田真
    • Organizer
      第7回多感覚研究会
    • Place of Presentation
      東京女子大学
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 自閉スペクトラム症の多感覚情報処理と身体像(コメンテータとして話題提供)2015

    • Author(s)
      和田真
    • Organizer
      第3回自閉症と音声研究会
    • Place of Presentation
      工学院大学
    • Year and Date
      2015-11-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 自閉症スペクトラムにおける視触覚の相互作用と身体イメージの可塑性2015

    • Author(s)
      和田真
    • Organizer
      熊本大学心の可塑性研究ユニット主催シンポジウム「脳がつむぐ知覚世界とその適応的変化」
    • Place of Presentation
      熊本大学
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] A rubber tail task in CAPS2 KO mice: an initial study2015

    • Author(s)
      Wada M, Ide M, Yagishita K, Katakai M, Shinoda Y, Furuichi T, Kansaku K .
    • Organizer
      第75回日本動物心理学会大会
    • Place of Presentation
      日本女子大学
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effect of a rubber hand on cross-modal dynamic captures2015

    • Author(s)
      Wada M, Ide M
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸国際展示場, 神戸
    • Year and Date
      2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effects of periodicity of brush stroking on the rubber hand illusion2015

    • Author(s)
      Ide M, Wada M
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸国際展示場, 神戸
    • Year and Date
      2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウスのラバーテイル課題2014

    • Author(s)
      和田真,大良宏樹,高野弘二,神作憲司
    • Organizer
      第6回多感覚研究会
    • Place of Presentation
      広島大学, 広島
    • Year and Date
      2014-11-12 – 2014-11-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 周期的触覚刺激がラバーハンド錯覚に及ぼす効果2014

    • Author(s)
      井手正和,和田真
    • Organizer
      第6回多感覚研究会
    • Place of Presentation
      広島大学, 広島
    • Year and Date
      2014-11-12 – 2014-11-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] A rubber tail task in mice: effect of visual occlusion.2014

    • Author(s)
      Wada M, Ora H, Takano K, Kansaku K
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜, 横浜
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] A rubber tail task in mice: effect of spatial location of the rubber tails.2014

    • Author(s)
      Wada M, Ora H, Takano K, Kansaku K
    • Organizer
      第74回日本動物心理学会大会
    • Place of Presentation
      犬山国際観光センター“フロイデ”, 犬山
    • Year and Date
      2014-07-19 – 2014-07-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mice may experience body ownership of the tails2014

    • Author(s)
      Wada M, Ora H, Takano K, Kansaku K
    • Organizer
      15th International Multisensory Forum
    • Place of Presentation
      Royal Tropical Institute, Amsterdam, Netherlands
    • Year and Date
      2014-06-13
    • Related Report
      2014 Annual Research Report
  • [Remarks] 国立リハ研究所・脳機能系障害研究部・発達障害研究室

    • URL

      http://www.rehab.go.jp/ri/noukinou/hattatsu/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 国リハ研究所・脳機能系障害研究部・発達障害研究室

    • URL

      http://www.rehab.go.jp/ri/noukinou/hattatsu/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 脳機能系障害研究部・発達障害研究室

    • URL

      http://www.rehab.go.jp/ri/noukinou/hattatsu/

    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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