Molecular Dynamics and basis of DNA tether structure for preventing radiation-induced chromosome fragmentation
| Project/Area Number |
26701006
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Hiroshima University |
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Principal Investigator |
Miyamoto Tatsuo 広島大学, 原爆放射線医科学研究所, 講師 (40452627)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2014: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | DNA修復 / 染色体断片化 |
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| Outline of Final Research Achievements |
DNA double-strand breaks during mitosis are known to be difficult to be repaired because of the high condensation of mitotic chromosomes. Interestingly, a spindle assembly checkpoint (SAC) molecule BubR1 induces a DNA tether structure to prevent chromosome fragmentation post ionizing radiation (IR) in Drosophila neuroblasts. This study revealed that human BubR1 does not induce the DNA tether but suppress the chromosome fragmentation post IR in a SAC-independent manner. Taken together, BubR1-dependent protection of chromosomes post IR is conserved among species, but the molecular mechanism develops in an organism-specific manner.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa2016
Author(s)
Sasaki T, Hanisch FG, Deutzmann R, Sakai LY, Sakuma T, Miyamoto T, Yamamoto T, Hannappel E, Chu ML, Lanig H, von der Mark K
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Journal Title
Matrix Biol
Volume: 56
Pages: 132-149
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] PLK1-dependent phosphorylation of WDR62, a causative gene product for primary microcephaly, maintains mitotic spindle orientation2016
Author(s)
Tatsuo Miyamoto, Kosuke Hosoba, Akihiro Fukumitsu, Yoshinori Masatsuna, Silvia Natsuko Akutsu, Hiroyuki Morino, Hideshi Kawakami, Takashi Yamamoto, Kenji Shimizu, Hirofumi Oohashi, Shinya Matsuura
Organizer
The 28th CDB meeting Cilia and centrosomes
Place of Presentation
Kobe
Year and Date
2016-11-27
Related Report
Int'l Joint Research
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[Presentation] A combined approach of exome sequencing and genome editing identified WDR62/MCPH2 mutations in patient with primary microcephaly2016
Author(s)
Tatsuo Miyamoto,Yoshinori Masatsuna, Akihiro Fukumitsu, Silvia Natsuko Akutsu, Kosuke Hosoba, Hiroyuki Morino, Hideshi Kawakami, Takashi Yamamoto, Kenji Shimizu, Hirofumi Oohashi, Shinya Matsuura
Organizer
ASHG2016
Place of Presentation
Vancouver (Canada)
Year and Date
2016-10-18
Related Report
Int'l Joint Research
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