| Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2014: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Outline of Final Research Achievements |
DNA double-strand breaks during mitosis are known to be difficult to be repaired because of the high condensation of mitotic chromosomes. Interestingly, a spindle assembly checkpoint (SAC) molecule BubR1 induces a DNA tether structure to prevent chromosome fragmentation post ionizing radiation (IR) in Drosophila neuroblasts. This study revealed that human BubR1 does not induce the DNA tether but suppress the chromosome fragmentation post IR in a SAC-independent manner. Taken together, BubR1-dependent protection of chromosomes post IR is conserved among species, but the molecular mechanism develops in an organism-specific manner.
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