| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Protein adsorption behaviors can be regulated by the coating of poly(2-methoxy ethyl acrylate) analogous polymers. And various cell functions (Hepatocyte: Hepatic gene expression, mesenchymal stem cell: adipogenesis) can be regulated through the control of cell shapes through the suppression of protein adsorption by PMEA analogous polymers.
Understanding of regulation mechanisms of extracellular matrix (ECM) gene expression is important to control of biomaterial interface remodeling during the culture. A part of ECM gene expression was regulated through the regulation of actin assembly. Additionally, initial cell adhesion mechanisms which can regulate cell shapes and actin assembly was assessed. Cells adhered on PMEA analogous polymers via both integrin-dependent and -independent mechanisms.
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