|Budget Amount *help
¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
|Outline of Final Research Achievements
I have been focusing on the lactate metabolism, and found that it functions as an inducer of cell signaling in skeletal muscle cells (e.g., increased mitochondrial biogenesis and myogenesis) and adipocytes (e.g., increased lipases expression). The aim of this study was to examine whether manipulation of blood lactate concentration can be a therapeutic strategy against obesity and metabolic disorder by reducing fat mass and preventing muscle atrophy. I found that the supplementation of lactate-based compound elicits muscle hypertrophy, reduces fat mass, and improves glucose metabolism. These findings suggest that lactate may be a beneficial molecule against obesity and metabolic disorder.