| Budget Amount *help |
¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
Focusing on patients whose intrahepatic lipid content was >5% (n=26), we assessed putative markers in blood, body composition, tissue specific lipid accumulation by 1H-MRS, insulin sensitivity by hyperinsulinemic euglycemic clamp, pathological diagnosis and gene expression using liver biopsies, and the plasma metabolome. As results, H-IS assessed by % suppression of endogenous glucose production during the clamp was preserved in some NAFLD patients. Among all the parameters, citric acid, cis-aconitic acid, and succinic acid, which are the components of TCA cycle assessed by metabolome, adipose IS (% suppression of non esterified fatty acid during the clamp), and adiponectin were significantly higher in the upper tertile of H-IS than the lower (P<0.05). Interestingly, hepatic pyruvate carboxylase mRNA expression was 27% lower in the H-IS preserved group. In contrast, BMI, ALT, CRP, typeIV collagen, muscle IS, and tissue NAFLD activity score were not different between the two groups.
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