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3D structural analysis of (macro)molecules using VCD in the region above 1900 cm-1

Research Project

Project/Area Number 26702034
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Biomolecular chemistry
Research InstitutionHokkaido University

Principal Investigator

Taniguchi Tohru  北海道大学, 先端生命科学研究科(研究院), 助教 (00587123)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Keywords有機化学 / 赤外円二色性 / キラリティー / タンパク質 / 構造解析 / 核酸 / 蛋白質 / 糖
Outline of Final Research Achievements

Development of a method to analyze molecular stereostructures provides a detailed understanding of the functions of various molecules such as medicines and enzymes and of the origin of life. This work has established a new convenient method for analyzing molecular stereostructures by using vibrational circular dichroism (VCD) spectroscopy. For example, this work has demonstrated its effectiveness toward the secondary structure of macromolecules such as polyesters. Another example for the use of our VCD method is facile determination of lipid molecules that are suggested to have involved in the development of life. Because VCD spectroscopy provides structural information that can not be obtained by the other available methods, this method should deepen our understandings on molecular stereostructures.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (29 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Acknowledgement Compliant: 8 results,  Open Access: 1 results) Presentation (12 results) (of which Invited: 11 results)

  • [Int'l Joint Research] ミュンヘン工科大学(ドイツ)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Formal (4+1) Cycloaddition and Enantioselective Michael-Henry-Cascade Reactions to Synthesize Spiro[4,5]decanes and Spirooxindole Polycycles2017

    • Author(s)
      Huang, J.-R.; Sohail, M.; Taniguchi, T.; Monde, K.; Tanaka, F.
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 56 Issue: 21 Pages: 5853-5857

    • DOI

      10.1002/anie.201701049

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 円二色性(CD)・赤外円二色性(VCD)による立体構造解析 ~実践例と注意点~2017

    • Author(s)
      谷口透、門出健次
    • Journal Title

      有機合成化学協会誌

      Volume: 印刷中

    • NAID

      130006903196

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Reinvestigation of the Absolute Configurations of Chiral s-Mercaptoalkanones Using Vibrational Circular Dichroism and 1H NMR Analysis2016

    • Author(s)
      Kiske, C., Noerenberg, S., Ecker, M., Ma, X., Taniguchi, T., Monde, K., Eisenreich, W., Engel, K.-H.
    • Journal Title

      J. Agric. Food Chem.

      Volume: 64 Issue: 45 Pages: 8563-8571

    • DOI

      10.1021/acs.jafc.6b03670

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Enantioselective Total Synthesis of (+)-Hinckdentine A via a Catalytic Dearomatization Approach2016

    • Author(s)
      Kazuya Douki, Hiroyuki Ono, Tohru Taniguchi, Jun Shimokawa, Masato Kitamura, Tohru Fukuyama
    • Journal Title

      Journal of the American Chemical Society

      Volume: 138 Issue: 44 Pages: 14578-14581

    • DOI

      10.1021/jacs.6b10237

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Diels-Alder Reaction of α-Substituted and β,β-Disubstituted α,β-Enals via Diarylprolinol Silyl Ether for the Construction of All-Carbon Quaternary Stereocenters2016

    • Author(s)
      Y. Hayashi, B. P. Bondzic, T. Yamazaki, Y. Gupta, S. Ogasawara, T. Taniguchi, K. Monde
    • Journal Title

      Chem. Eur. J.

      Volume: 22 Issue: 44 Pages: 15874-15880

    • DOI

      10.1002/chem.201602345

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Bioinspired Synthesis of (±)-Rubrobramide, (±)-Flavipucine, and Isoflavipucine2016

    • Author(s)
      Mizutani, S., Komori, K., Taniguchi, T., Monde, K., Kuramochi, K., Tsubak, K.
    • Journal Title

      Angew. Chem., Int. Ed.

      Volume: 55 Issue: 33 Pages: 9553-9556

    • DOI

      10.1002/anie.201602910

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Studying the stereostructures of biomolecules and their analogs by vibrational circular dichroism.2016

    • Author(s)
      Taniguchi, T., Hongen, T., Monde, K.
    • Journal Title

      Polym. J.

      Volume: 48 Issue: 9 Pages: 925-931

    • DOI

      10.1038/pj.2016.61

    • NAID

      40020949893

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic stimulation of polyketide production in Chaetomium cancroideum by an NAD+-dependent HDAC inhibitor2016

    • Author(s)
      T. Asai, S. Morita, T. Taniguchi, K. Monde, Y. Oshima,
    • Journal Title

      Org. Biomol. Chem

      Volume: 14 Issue: 2 Pages: 646-651

    • DOI

      10.1039/c5ob01595b

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hydrogen Bonding to Carbonyl Oxygen of Nitrogen-Pyramidalized Amide – Detection of Pyramidalization Direction Preference by Vibrational Circular Dichroism Spectroscopy.2016

    • Author(s)
      Wang S., Taniguchi T. , Monde K. ,Kawahata M., Yamaguchi K., Otani Y.,Ohwada T.
    • Journal Title

      Chem. Commun.

      Volume: 52 Issue: 21 Pages: 4018-4021

    • DOI

      10.1039/c6cc00284f

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Studying the stereostructure of biomolecules and their analogues by vibrational circular dichroism.2016

    • Author(s)
      Tohru Taniguchi, Takahiro Hongen, Kenji Monde
    • Journal Title

      Polym. J.

      Volume: 48

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stereochemical Analysis of Glycerophospholipids by Vibrational Circular Dichroism2015

    • Author(s)
      Taniguchi T., Manai D., Shibata M., Itabashi Y., Monde K.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 137 Issue: 38 Pages: 12191-12194

    • DOI

      10.1021/jacs.5b05832

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 赤外円二色性による天然物の三次元構造解明2015

    • Author(s)
      谷口透
    • Journal Title

      現代化学

      Volume: 531 Pages: 34-35

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 赤外円二色性を用いた構造解析から拓く天然物化学(仮)2015

    • Author(s)
      谷口透
    • Journal Title

      現代化学

      Volume: 531

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Short Synthesis of Berkeleyamide D and Determination of the Absolute Configuration by the Vibrational Circular Dichroism Exciton Chirality Method.2014

    • Author(s)
      Kenta Komori, Tohru Taniguchi, Shoma Mizutani, Kenji Monde, Kouji Kuramochi, Kazunori Tsubaki
    • Journal Title

      Org. Lett.

      Volume: 16 Issue: 5 Pages: 1386-1389

    • DOI

      10.1021/ol500148g

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In Depth Study on Solution-State Structure of Poly(lactic acid) by Vibrational Circular Dichroism2014

    • Author(s)
      Hongen, T., Taniguchi, T. Nomura, S., Kadokawa, J., Monde, K.
    • Journal Title

      Macromolecules

      Volume: 47 Issue: 15 Pages: 5313-5319

    • DOI

      10.1021/ma501020s

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 簡単に溶液状態の分子の立体構造を解析:赤外円二色性キラル分光法2014

    • Author(s)
      谷口透
    • Journal Title

      現代化学

      Volume: 518 Pages: 47-51

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Presentation] 立体構造解析から拓く天然物化学2016

    • Author(s)
      谷口透
    • Organizer
      第4回慶應有機化学若手シンポジウム
    • Place of Presentation
      慶応義塾大学(神奈川県横浜市)
    • Year and Date
      2016-05-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 立体構造解析から拓く天然物化学2016

    • Author(s)
      谷口透
    • Organizer
      第4回慶応有機化学若手シンポジウム
    • Place of Presentation
      慶応義塾大学(神奈川県横浜市)
    • Year and Date
      2016-05-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] キラル分光法を用いた生理活性物質・糖・ペプチドの構造解析2016

    • Author(s)
      谷口透
    • Organizer
      第23回農芸化学Frontiersシンポジウム
    • Place of Presentation
      定山渓ビューホテル(北海道札幌市)
    • Year and Date
      2016-03-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Stereochemical Analysis of Glycerophospholipids by the VCD Exciton Chirality Method2016

    • Author(s)
      Tohru Taniguchi, Daisuke Manai, Masataka Shibata, Kenji Monde
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      同志社大学(京都府京田辺市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 赤外円二色性で見るキラル高分子の立体構造2015

    • Author(s)
      谷口透
    • Organizer
      2015年度北海道高分子若手研究会
    • Place of Presentation
      定山渓グランドホテル瑞苑(北海道札幌市)
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 赤外円二色性によるキラル構造解析から拓く生体高分子化学2015

    • Author(s)
      谷口透
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 赤外円二色性による立体配置・立体配座決定法の開発2015

    • Author(s)
      谷口透
    • Organizer
      日本化学会第95回春季年会
    • Place of Presentation
      日本大学(千葉県船橋市)
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Easy Access to Molecular Stereostructure by Vibrational Circular Dichroism2014

    • Author(s)
      Tohru Taniguchi
    • Organizer
      8th Singapore International Chemistry Conference 2014
    • Place of Presentation
      シンガポール国立大学(シンガポール)
    • Year and Date
      2014-12-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 赤外円二色性キラル構造解析から拓く天然物化学2014

    • Author(s)
      谷口透
    • Organizer
      天然物ケミカルバイオロジー 第6回若手研究者ワークショップ
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府豊中市)
    • Year and Date
      2014-10-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Seeing what other methods can not see: VCD calculation and the VCD exciton chirality method2014

    • Author(s)
      Tohru Taniguchi
    • Organizer
      The Fourth International Conference on Vibrational Optical Activity (VOA-4)
    • Place of Presentation
      河北大学(中国)
    • Year and Date
      2014-10-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 赤外円二色性による天然有機化合物の三次元構造解析2014

    • Author(s)
      谷口透
    • Organizer
      日本農芸化学会 若手の会
    • Place of Presentation
      定山渓ビューホテル(北海道札幌市)
    • Year and Date
      2014-09-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] キラル構造解析から拓く天然物化学2014

    • Author(s)
      谷口透
    • Organizer
      第49回天然物化学談話会
    • Place of Presentation
      せとうち児島ホテル(岡山県倉敷市)
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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