Neural mechanisms of salience acquired through reward-based associative learning
Project/Area Number |
26702039
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Partial Multi-year Fund |
Research Field |
Basic / Social brain science
|
Research Institution | Kyoto University (2016-2017) National Institute for Physiological Sciences (2014-2015) |
Principal Investigator |
OGAWA Masaaki 京都大学, 医学研究科, 講師 (00716186)
|
Research Collaborator |
ISHINO Seiya 京都大学, 医学研究科, 研究員
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
|
Keywords | 報酬 / 注意 / 連合学習 / 神経科学 / 眼窩前頭皮質 |
Outline of Final Research Achievements |
Despite theoretical and behavioral advances of studies about salience of a cue acquired through associative learning between the cue and reward, the neural mechanisms underlying the salience remained elusive. We show that spiking activities of optogenetically-identified midbrain dopamine neurons may contribute to heighten the salience of a cue associated with uncertain reward. We also show that the orbitofrontal cortex causally contributes to reversal of stimulus-outcome associations in a context- and temporally specific manner.
|
Report
(5 results)
Research Products
(13 results)