Probing single bio-moleculer functions using advanced vibrational spectroscopies

• Project/Area Number: 26706006
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Nanobioscience
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: Yano Takaaki 東京工業大学, 物質理工学院, 助教 (90600651)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥22,880,000 (Direct Cost: ¥17,600,000、Indirect Cost: ¥5,280,000); Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2014: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
• Keywords: ナノバイオフォトニクス / プラズモニクス / ナノバイオ / 応用光学・量子光工学 / 表面増強ラマン散乱 / 振動分光 / 単一分子分光 / ナノフォトニクス / ナノバイオサイエンス

Outline of Final Research Achievements

Biomolecules are known to express their biological functions through the structural fluctuations. In this research, we developed a vibrational spectroscopic method to analyze bio-molecular functions and dynamics using field-enhanced Raman effects caused by plasmonic nanostructures. This method developed here will open a new way to deeply understand underlaying mechanisms of biomolecular recognition reactions.

Research Products

• [Journal Article] Enhanced optical magnetism for reversed optical binding forces between silicon nanoparticles in the visible region (2017)
  • Author(s): T. Yano, Y. Tsuchimoto, R. P. Zaccaria, A. Toma, A. Portela, and M. Hara,
  • Journal Title: Optics Express Volume: 25 Issue: 1 Pages: 431-439
  • DOI: 10.1364/oe.25.000431
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fano resonant all-dielectric core/shell nanoparticles with ultrahigh scattering directionality in the visible region (2016)
  • Author(s): Tsuchimoto, Y. Yano, T. A. Hayashi, T. Hara, M.
  • Journal Title: Opt Express Volume: 24 Issue: 13 Pages: 14451-62
  • DOI: 10.1364/oe.24.014451
  • Peer Reviewed / Open Access
• [Journal Article] Dynamics of Strong Coupling between CdSe Quantum Dots and Surface Plasmon Polaritons in Subwavelength Hole Array (2016)
  • Author(s): H. Wang, H.Y. Wang, A. Toma, T. Yano, Q.D. Chen, H.L. Xu, H.B. Sun, and R. P. Zaccaria
  • Journal Title: J. Phys. Chem. Lett. Volume: 7 Issue: 22 Pages: 4648-4654
  • DOI: 10.1021/acs.jpclett.6b02059
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Laser Scanning Assisted Tip-Enhanced Optical Microscopy for Robust Optical Nanospectroscopy (2016)
  • Author(s): Taka-aki Yano, Yuta Tsuchimoto, Masahito Mochizuki, Tomohiro Hayashi, Masahiko Hara.
  • Journal Title: Applied Spectroscopy Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Highly sensitive SERS analysis of the cyclic Arg-Gly-Asp peptide ligands of cells using nanogap antennas (2016)
  • Author(s): Alejandro Portela, Taka-aki Yano, Christian Santschi, Olivier J. F. Martin, Hitoshi Tabata, and Masahiko Hara
  • Journal Title: Journal of Biophotonics Volume: 掲載確定 Issue: 2 Pages: 294-302
  • DOI: 10.1002/jbio.201500327
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Controlling the Visible Electromagnetic Resonances of Si/SiO2 Dielectric Core-Shell Nanoparticles by Thermal Oxidation (2015)
  • Author(s): Tsuchimoto, Y., Yano, T., Hada, M., Nakamura, K.G., Hayashi, T., Hara, M.
  • Journal Title: Small Volume: 11 Issue: 37 Pages: 4844-4849
  • DOI: 10.1002/smll.201500884
  • Peer Reviewed
• [Journal Article] 局在表面プラズモンを利用した超解像顕微分光とイメージング (2015)
  • Author(s): 市村垂生, 矢野隆章
  • Journal Title: 分光研究 Volume: 64 Pages: 582-598
  • NAID: 40020722646
  • Peer Reviewed
• [Journal Article] Spectral tunability of realistic plasmonic nanoantennas (2014)
  • Author(s): Alejandro Portela1, Takaaki Yano, Christian Santschi3, Hiroaki Matsui1, Tomohiro Hayashi, Masahiko Hara, Olivier J. F. Martin and Hitoshi Tabata
  • Journal Title: Appl. Phys. Lett. Volume: 105 Issue: 9 Pages: 091105-091105
  • DOI: 10.1063/1.4894633
  • Peer Reviewed
• [Presentation] 原子層物質表面の近接場ナノ分光計測 (2016)
  • Author(s): 矢野 隆章
  • Organizer: 物性研究所短期研究会
  • Place of Presentation: 東京大学柏キャンパス
  • Year and Date: 2016-12-20
  • Invited
• [Presentation] Tip-enhanced Raman spectroscopy for nano-analysis and nano-imaging (2016)
  • Author(s): Taka-aki Yano,
  • Organizer: IUMRS-ICYRAM 2016
  • Place of Presentation: Bangalore, India
  • Year and Date: 2016-12-11
  • Int'l Joint Research / Invited
• [Presentation] All-dielectric nanostructures for low-loss field enhanced spectroscopy and imaging (2016)
  • Author(s): Taka-aki Yano, Yuta Tsuchimoto, Tomohiro Hayashi and Masahiko Hara
  • Organizer: SPIE: Optics and Photonics
  • Place of Presentation: San Diego. USA
  • Year and Date: 2016-08-28
  • Int'l Joint Research / Invited
• [Presentation] In-situ TERS Observation of Mechanically- and Electrically-induced Chemical Reactions (2016)
  • Author(s): Taka-aki Yano
  • Organizer: PIERS 2016
  • Place of Presentation: Shanghai, China
  • Year and Date: 2016-08-08
  • Int'l Joint Research / Invited
• [Presentation] Tunable electromagnetic responses of high-index dielectric nanostructures in the visible region (2015)
  • Author(s): Yuta Tsuchimoto, Taka-aki Yano, Tomohiro Hayashi, Masahiko Hara
  • Organizer: The 10th Asia-Pacific Conference on Near-field Optics (APNFO10)
  • Place of Presentation: 函館市国際水産・海洋総合研究センター(北海道)
  • Year and Date: 2015-07-08
  • Int'l Joint Research
• [Presentation] プラズモン光増強場を用いたナノ力学分光 (2015)
  • Author(s): 矢野 隆章, 土本 悠太, 林 智広, 原 正彦
  • Organizer: レーザー学会第３５回年次大会
  • Place of Presentation: 東海大学（東京都）
  • Year and Date: 2015-01-12
  • Invited