Development for early detection of apoptosis by high sensitive miniature magnetic resonance force measurement system

• Project/Area Number: 26706023
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: General applied physics
• Research Institution: Tohoku University
• Principal Investigator: Toda Masaya 東北大学, 工学(系)研究科(研究院), 准教授 (40509890)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2014: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
• Keywords: カンチレバー / 磁気共鳴 / マイクロ流路 / 磁気プローブ / アポトーシス / 活性酸素濃度 / カンチレバーセンサ / 電子スピン共鳴

Outline of Final Research Achievements

To develop the flowcytometry tmechnich basedon magnetic resonance force measurement method, 1. Fabrication of high sensitive cantilever force sensor, 2, fabrication of microchamber with thin Si window for magnetic resonance force detection in high vacuum, 3, fabrication of diamond probe with NV color center have been done in this research project.

Research Products

• [Journal Article] Fabrication of Assembled Scanning Probe with Nitrogen Vacancy Centers in Diamond Particle (2016)
  • Author(s): Minjie Zhu, Masaya Toda, Takahito Ono
  • Journal Title: IEEE Transactions on Nanotechnology Volume: 99 Issue: 4 Pages: 1-6
  • DOI: 10.1109/tnano.2016.2640191
  • Peer Reviewed
• [Journal Article] Magnetic field sensor based on vacuum packaged cantilever with a mounted magnet (2016)
  • Author(s): Gaopeng Xue, Masaya Toda, Nurasyikin Mohd, Zhonglie An, Nguyen Van Toan, Takahito Ono
  • Journal Title: 「センサ・マイクロマシンと応用システム」シンポジウム論文集 Volume: 33 Pages: 1-4
  • NAID: 40021216861
  • Peer Reviewed
• [Journal Article] Comb-Drive XYZ-microstage With Large Displacements Based on Chip-Level Microassembly (2016)
  • Author(s): Gaopeng Xue, Masaya Toda, Takahito Ono
  • Journal Title: Journal of Microelectromechanical Systems Volume: 25 Issue: 6 Pages: 989-998
  • DOI: 10.1109/jmems.2016.2607233
  • Peer Reviewed
• [Journal Article] Scanning Probe with Nitrogen Vacancy Centers in Diamond Particle for Magnetic Resonance Imaging (2016)
  • Author(s): Minjie Zhu, Masaya Toda, and Takahito Ono
  • Journal Title: Proceedings of the IEEE International Conference on Nanotechnology Volume: 16 Pages: 210-213
  • DOI: 10.1109/nano.2016.7751404
  • Peer Reviewed
• [Journal Article] Assembled Comb-drive XYZ-microstage with DPPH Sample for the 3D Scanning of Magnetic Resonance Force Microscope (2016)
  • Author(s): Gaopeng Xue, Masaya Toda, and Takahito Ono
  • Journal Title: Proceedings of the IEEE International Conference on Nanotechnology Volume: 16 Pages: 980-981
  • DOI: 10.1109/nano.2016.7751422
  • Peer Reviewed
• [Journal Article] Fabrication and evaluation of CVD diamond resonators (2016)
  • Author(s): Yuya Mochimaru, Masaya Toda and Takahito Ono
  • Journal Title: Proceedings of the IEEE International Conference on Nanotechnology Volume: 10 Pages: 676-677
  • DOI: 10.1109/nano.2016.7751555
  • Peer Reviewed
• [Journal Article] Packaging Technique of Micro Cantilever for Magnetic Force Sensing (2016)
  • Author(s): Nurasyikin Mohd, Naoki Inomata, Nguyen Van Toan, Takahito Ono and Masaya Toda
  • Journal Title: Proceedings of the International Workshop on Nanomechanical Sensors Volume: 12 Pages: 150-151
• [Journal Article] Investigation of bimaterial cantilever beam for heat sensing in liquid (2016)
  • Author(s): Ioana Voiculescua, Fei Liu, Takahito Ono, Masaya Toda
  • Journal Title: Sensors and Actuators Volume: 242 Pages: 58-66
  • DOI: 10.1016/j.sna.2015.11.030
  • Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 磁気共鳴イメージングための NVセンターを有するダイヤモンドプローブ (2015)
  • Author(s): 朱 敏杰, 戸田 雅也, 小野 崇人
  • Journal Title: 日本機械学会2015年度年次大会講演論文集 Volume: 15
  • NAID: 40020857713
  • Acknowledgement Compliant
• [Journal Article] Diamond Probe with Nitrogen Vacancy Center for Magnetic Resonance Imaging (2015)
  • Author(s): Minjie Zhu, Masaya Toda and Takahito Ono
  • Journal Title: 「センサ・マイクロマシンと応用システム」シンポジウム論文集 Volume: 32
  • NAID: 40020857713
  • Acknowledgement Compliant
• [Journal Article] ASSEMBLED COMB-DRIVE XYZ-MICROSTAGE WITH LARGE DISPLACEMENTS FOR LOW TEMPERATURE MEASUREMENT SYSTEMS (2015)
  • Author(s): Gaopeng Xue, Masaya Toda, and Takahito Ono
  • Journal Title: Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems Volume: 28 Pages: 14-17
  • DOI: 10.1109/memsys.2015.7050874
  • Peer Reviewed / Open Access
• [Journal Article] MICRO FLUIDIC CHAMBER WITH THIN SI WINDOWS FOR OBSERVATION OF BIOLOGICAL SAMPLES IN VACUUM (2015)
  • Author(s): Hideki Hayashi, Masaya Toda, and Takahito Ono
  • Journal Title: Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems Volume: 28 Pages: 344-347
  • DOI: 10.1109/memsys.2015.7050959
  • Peer Reviewed / Open Access
• [Journal Article] Si nanowire probe with NdFeB magnet for attonewton-scale force detection (2015)
  • Author(s): Yong-Jun Seo, Masaya Toda and Takahito Ono
  • Journal Title: Journal of Micromechanics and Microengineering Volume: 4 Issue: 4 Pages: 1-5
  • DOI: 10.1088/0960-1317/25/4/045015
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Ultorasensitive Si Nanowire Probe for Magnetic Resonance Detection (2014)
  • Author(s): Yongjun Seo、Masaya Toda、Yusuke Kawai、Takahito Ono
  • Journal Title: Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems Volume: 27 Pages: 151-154
  • DOI: 10.1109/memsys.2014.6765596
  • Peer Reviewed / Open Access
• [Journal Article] Fabrication of Silicon Nanowire Probe with Magnet for Magnetic Resonance Force Microscopy (2014)
  • Author(s): Yong-Jun Seo, Masaya Toda, Yusuke Kawai, Takahito Ono
  • Journal Title: IEEJ Transactions on Sensors and Micromachines Volume: 134 Issue: 6 Pages: 166-167
  • DOI: 10.1541/ieejsmas.134.166
  • NAID: 130004438741
  • ISSN: 1341-8939, 1347-5525
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Scanning Probe with Nitrogen Vacancy Centers in Diamond Particle for Magnetic Resonance Imaging (2016)
  • Author(s): Minjie Zhu, Masaya Toda, and Takahito Ono
  • Organizer: IEEE International Conference on Nanotechnology
  • Place of Presentation: 仙台国際センター、仙台
  • Year and Date: 2016-08-22
  • Int'l Joint Research
• [Presentation] Fabrication and evaluation of CVD diamond resonators (2016)
  • Author(s): Yuya Mochimaru, Masaya Toda and Takahito Ono
  • Organizer: IEEE International Conference on Nanotechnology
  • Place of Presentation: 仙台国際センター、仙台
  • Year and Date: 2016-08-22
  • Int'l Joint Research
• [Presentation] Assembled Comb-drive XYZ-microstage with DPPH Sample for the 3D Scanning of Magnetic Resonance Force Microscope (2016)
  • Author(s): Gaopeng Xue, Masaya Toda, and Takahito Ono
  • Organizer: IEEE International Conference on Nanotechnology
  • Place of Presentation: 仙台国際センター、仙台
  • Year and Date: 2016-08-22
  • Int'l Joint Research
• [Presentation] Packaging Technique of Micro Cantilever for Magnetic Force Sensing (2016)
  • Author(s): Nurasyikin Mohd, Naoki Inomata, Nguyen Van Toan, Takahito Ono and Masaya Toda
  • Organizer: International Workshop on Nanomechanical Sensors
  • Place of Presentation: デルフト、オランダ
  • Year and Date: 2016-06-22
  • Int'l Joint Research
• [Presentation] CVDダイヤモンド振動子の作製と評価 (2016)
  • Author(s): 持丸 裕矢, 戸田 雅也, 小野 崇人
  • Organizer: 日本機械学会東北支部第51期総会・講演会講演論文集
  • Place of Presentation: 東北大学，仙台
  • Year and Date: 2016-03-11
• [Presentation] Probe with Nitrogen Vacancy in Diamond Thin Film for Magnetic Resonance Imaging (2015)
  • Author(s): Minjie Zhu, Masaya Toda and Takahito Ono
  • Organizer: Japan-China-Korea Joint Conference on MEMS/NEMS 2015
  • Place of Presentation: Xi'an, China
  • Year and Date: 2015-09-23
  • Int'l Joint Research
• [Presentation] Assembled comb-drive XYZ-microstage integrated with capacitive displacement sensor for low temperature measurement systems (2014)
  • Author(s): Gaopeng Xue,Masaya Toda, Takahito Ono
  • Organizer: 「センサ・マイクロマシンと応用システム」シンポジウム
  • Place of Presentation: くにびきメッセ，島根
  • Year and Date: 2014-10-20 – 2014-10-22
• [Presentation] 真空中細胞観察のための薄膜Si窓を有する マイクロチャネル型チャンバー (2014)
  • Author(s): 林秀樹, 戸田雅也, 小野崇人
  • Organizer: 「センサ・マイクロマシンと応用システム」シンポジウム
  • Place of Presentation: くにびきメッセ，島根
  • Year and Date: 2014-10-20 – 2014-10-22
• [Presentation] CALIBRATION STUDY OF BIMATERIAL CANTILEVER BEAM NANOCALORIMETER USED IN LIQUID APPLICATIONS (2014)
  • Author(s): Masaya Toda, Ioana Voiculescu, Fei Liu, Takahito Ono
  • Organizer: 11st International Workshop on Nanomechanical Sesing
  • Place of Presentation: Madrid, Sapin
  • Year and Date: 2014-04-30 – 2014-05-02