| Budget Amount *help |
¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Outline of Final Research Achievements |
We have developed new organoiron catalytic species for efficient, selective, and versatile C(sp2)-H and C(sp3)-H bond functionalization. For C(sp2)-H activation, we used stabilizing ligands and a mild organometallic reagent in order to prevent reduction of iron to a highly reactive and difficult to control low-valent state, and we achieved a high-valent organoiron species that catalyzes the reaction of various carboxamides with organometallic reagents or with electrophiles. We also developed a triphosphine ligand that enables the iron-catalyzed activation of a variety of weakly coordinating substrates such as ketones or carboxylic acids.
For the the cleavage of a C(sp3)-H bond, we used the dual radical/organometallic reactivity of organoiron to achieve the remote of functionalization of the gamma C-H bond in alkylarenes with high regioselectivity.
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