Iron-Catalyzed C-H Activation using Organoboron Compounds
| Project/Area Number |
26708011
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Ilies Laurean 東京大学, 大学院理学系研究科(理学部), 准教授 (40569951)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | 有機合成 / 合成化学 |
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| Outline of Final Research Achievements |
We have developed new organoiron catalytic species for efficient, selective, and versatile C(sp2)-H and C(sp3)-H bond functionalization. For C(sp2)-H activation, we used stabilizing ligands and a mild organometallic reagent in order to prevent reduction of iron to a highly reactive and difficult to control low-valent state, and we achieved a high-valent organoiron species that catalyzes the reaction of various carboxamides with organometallic reagents or with electrophiles. We also developed a triphosphine ligand that enables the iron-catalyzed activation of a variety of weakly coordinating substrates such as ketones or carboxylic acids.
For the the cleavage of a C(sp3)-H bond, we used the dual radical/organometallic reactivity of organoiron to achieve the remote of functionalization of the gamma C-H bond in alkylarenes with high regioselectivity.
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Report
(5 results)
Research Products
(66 results)
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[Presentation] ジ亜鉛中間体を経た選択的な置換インドール合成2015
Author(s)
101. Mayuko Isomura, Shinichi Yamauchi, Laurean Ilies, Masaharu Nakamura, Eiichi Nakamura
Organizer
日本化学会第95春季年会
Place of Presentation
日本大学（千葉）
Year and Date
2015-03-26 – 2015-03-29
Related Report
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[Presentation] Iron-Catalyzed C-H Activation2015
Author(s)
Laurean Ilies, Eiichi Nakamura
Organizer
The 13th Ibn Sina International Conference on Pure and Applied Heterocyclic Chemistry,
Place of Presentation
Hurghada (Egypt)
Year and Date
2015-02-14 – 2015-02-17
Related Report
Invited
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[Book] Organic Reactions2014
Author(s)
Eiichi Nakamura, Takuji Hatakeyama, Shingo Ito, Kentaro Ishizuka, Laurean Ilies, Masaharu Nakamura
Total Pages
206
Publisher
John Wiley&Sons
Related Report
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