| Budget Amount *help |
¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
|
|---|
| Outline of Final Research Achievements |
Magic-angle spinning solid-state NMR is a valid technique for structural and dynamical studies of non-crystalline/insoluble molecular systems such as membrane proteins at atomic resolution, but suffers from its low sensitivity. A number of nuclear hyper-polarization techniques using the high electron polarization is known, but limited by their own limitations. This work focuses on the so-far under-exploited “solid-state CIDNP" phenomenon based on the photo-chemically induced transient electron polarization, and has developed a novel polarizing agents that do not rely on the protein scaffold required for the conventional solid-state CIDNP experiments. This would be the basis for the first generic and chemically pure polarizing agent for solid-state CIDNP that only uses ordinary small organic molecules, which is easy to store/handle. In addition, a novel organic glass matrix that is hard and efficient for distribution of the local polarization to the bulk sample has also been developed.
|
