Dye-Containing Organic-Inorganic Hybrid Materials for Photoacoustic Imaging Probes
| Project/Area Number |
26708024
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Organic and hybrid materials
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| Research Institution | Kyoto University |
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Principal Investigator |
MIKI KOJI 京都大学, 工学(系)研究科(研究院), 准教授 (60422979)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2014: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | 近赤外色素 / 両親媒性 / ヒアルロン酸 / ナノ粒子 / 腫瘍 / 光音響 / 近赤外 / 生体高分子 / ハイブリッド / 造影剤 / 色素 / イメージング / 高分子 / 複合体 |
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| Outline of Final Research Achievements |
Organic-inorganic hybrid materials consisting of hyaluronic acid, poly(ethylene glycol), and cyanine dyes, which absorb near-infrared light and generate ultrasound, so-called photoacoustic signal, were prepared. This materials formed nanoparticles in water, which generated photoacoustic signal efficiently under near-infrared pulse laser irradiation. When these nanoparticles injected to tumor-bearing mice, nanoparticles efficiently accumulated in tumor sites and visualized them in high contrast.
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Report
(4 results)
Research Products
(74 results)
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[Presentation] Complexation of Single-Walled Carbon Nanotubes with [8], [9], and [10]Cycloparaphenyleneacetylenes2016
Author(s)
Miki, K.; Saiki, K.; Umeyama, T.; Baek, J.; Noda, T.; Imahori, H.; Ohe, K.
Organizer
International Synposium on the Synthesis and Application of Curved Organic π-Molecules and Materials (CURO-Pi II)
Place of Presentation
Oregon, USA
Year and Date
2016-09-11
Related Report
Int'l Joint Research
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