| Budget Amount *help |
¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2014: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Outline of Final Research Achievements |
Organic-inorganic hybrid materials consisting of hyaluronic acid, poly(ethylene glycol), and cyanine dyes, which absorb near-infrared light and generate ultrasound, so-called photoacoustic signal, were prepared. This materials formed nanoparticles in water, which generated photoacoustic signal efficiently under near-infrared pulse laser irradiation. When these nanoparticles injected to tumor-bearing mice, nanoparticles efficiently accumulated in tumor sites and visualized them in high contrast.
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