Three-dimensional cell assembly and muscle tissue formation for biohybrid robotic system
Project/Area Number |
26709013
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Partial Multi-year Fund |
Research Field |
Intelligent mechanics/Mechanical systems
|
Research Institution | Shinshu University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2014: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
|
Keywords | バイオハイブリッド / 組織工学 / バイオMEMS / 磁気アルキメデス効果 / 細胞アセンブリ / バイオアクチュエータ / マイクロマシン / マイクロ・ナノデバイス / バイオMEMS |
Outline of Final Research Achievements |
Bio-hybrid devices are based on the integration of living biological objects and artificial mechanical structures. We aim to construct a muscle tissue directly on a microstructure to realize a biohybrid device that utilizes muscle tissue as its actuator. In this study, we assembled rat cardiomyocytes around two micropillars three-dimensionally by magnetic levitation based on the magneto-Archimedes effect. Finally, we confirmed that the constructed myocardial tissues contracted in response to the electrical stimulation and the contractions deformed the micropillars.
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Report
(5 results)
Research Products
(35 results)