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Non-contact Single Cell Manipulation by High Speed On-chip Microrobot

Research Project

Project/Area Number 26709014
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionKyushu Institute of Technology

Principal Investigator

Kawahara Tomohiro  九州工業大学, 大学院生命体工学研究科, 准教授 (20575162)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Keywordsマイクロロボット / 流体制御 / マイクロ流体チップ
Outline of Final Research Achievements

In this research, we have developed a non-contact manipulation method by using fluid field generated by on-chip microrobot for fine positioning of single particle and living cell. The newly developed experimental platform with a high-speed actuator and a high-speed camera was used to investigate the basic characteristics of the generated fluid field. As a result, we found that it is highly required to compensate the disturbance of fluid flow for improving the positioning accuracy of single target during the manipulation. By adjusting the control parameter (amplitude and frequency) of the microrobot in real time, we succeeded in 10 um order positioning of single microparticle by non-contact actuation. Finally, the developed manipulation technique was applied to stimulate a single swimming-microorganism under the stable environment of closed microchip. The unique dynamic behavior of Paramecium was observed after the local point stimulation.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (13 results)

All 2016 2015 2014 Other

All Presentation (9 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Book (2 results) Remarks (2 results)

  • [Presentation] Motile Cell Tracking and Stimulation using High Speed Microrobotic Platform2016

    • Author(s)
      B. Ahmad and T. Kawahara
    • Organizer
      3rd Int. Conf. on Computational Methods in Engineering and Health Sciences (ICCMEH)
    • Place of Presentation
      Kyushu Institute of Technology, Tobata Campus (Kitakyushu)
    • Year and Date
      2016-12-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Real-time Observation and Stimulation of a Single Motile Cell using High-speed Microrobotic Platform2016

    • Author(s)
      B. Ahmad, T. Kawahara, T. Yasuda, and F. Arai
    • Organizer
      IEEE Int. Symp. on Micro-Nano Mechatronics and Human Science (MHS)
    • Place of Presentation
      Noyori Conference Hall (Nagoya)
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 遊泳微生物の高速・高倍率トラッキング2016

    • Author(s)
      川原知洋,アヒマドベラル,安田隆,新井史人
    • Organizer
      日本機械学会2016年度年次大会
    • Place of Presentation
      九州大学伊都キャンパス
    • Year and Date
      2016-09-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] Single Motile Cell Analysis using High Speed Microrobotic Platform2015

    • Author(s)
      B. Ahmad, T. Kawahara, T. Yasuda, and F. Arai
    • Organizer
      第32回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      Kitakyushu
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] High-Speed Microrobotic Platform for Mechanical Manipulation of Single Microorganism2015

    • Author(s)
      T. Kawahara, B. Ahmad, and F. Arai
    • Organizer
      17th International Symposium on Robotics Research
    • Place of Presentation
      Kitakyushu
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microrobotic Platform for Biomedical Applications2015

    • Author(s)
      T. Kawahara
    • Organizer
      1st International Symposium for Women Researchers on Advanced Science and Technology
    • Place of Presentation
      Genova
    • Year and Date
      2015-07-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] On-line Tracking and Stimulation of Swimming-Microorganism by On-Chip Microrobot2014

    • Author(s)
      B. Ahmad, T. Kawahara, T. Yasuda, and F. Arai
    • Organizer
      IEEE International Symposium on Micro-Nano Mechatronics and Human Science
    • Place of Presentation
      Nagoya
    • Year and Date
      2014-11-09 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Microrobotic Platform for Mechanical Stimulation of Swimming-Microorganism on a Chip2014

    • Author(s)
      B. Ahmad, T. Kawahara, T. Yasuda, and F. Arai
    • Organizer
      IEEE/RSJ International Conference on Intelligent Robots and Systems
    • Place of Presentation
      Chicago
    • Year and Date
      2014-09-14 – 2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mechanical Stimulation of Swimming Microorganism by On-Chip Microrobot2014

    • Author(s)
      B. Ahmad, T. Kawahara, T. Yasuda, and F. Arai
    • Organizer
      第32回日本ロボット学会学術講演会
    • Place of Presentation
      九州産業大学
    • Year and Date
      2014-09-04 – 2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Book] 細胞の特性計測・操作と応用(2.2節 磁気駆動マイクロロボットによる操作)2016

    • Author(s)
      川原知洋,新井史人
    • Total Pages
      250
    • Publisher
      コロナ社
    • Related Report
      2016 Annual Research Report
  • [Book] Micro- and Nanomanipulation Tools (Chapter 6: On-Chip Microrobot Driven by Permanent Magnets for Biomedical Applications)2015

    • Author(s)
      M. Hagiwara, T. Kawahara, and F. Arai
    • Total Pages
      608
    • Publisher
      Wiley
    • Related Report
      2015 Annual Research Report
  • [Remarks] 川原研究室webページ

    • URL

      http://www.lsse.kyutech.ac.jp/~kawahara/

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 九州工業大学若手研究者フロンティア研究アカデミー

    • URL

      http://www.kyutech.ac.jp/ttacademy/

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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