Nanoelectronics for multisite intracellular recording in brain tissue in vivo
| Project/Area Number |
26709024
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Electron device/Electronic equipment
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| Research Institution | Toyohashi University of Technology |
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Principal Investigator |
Kawano Takeshi 豊橋技術科学大学, 工学(系)研究科(研究院), 准教授 (70452216)
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| Research Collaborator |
NUMANO RIKA 豊橋技術科学大学, 大学院工学研究科, 准教授 (30462716)
KOIDA KOWA 豊橋技術科学大学, エレクトロニクス先端融合研究所, 准教授 (10455222)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2014: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Keywords | ナノデバイス / 細胞内電極 / 細胞内計測 / シリコン / MOSFET / センシングデバイス |
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| Outline of Final Research Achievements |
In this research, it is aimed to develop a nanoscale needle device with the needle length of more than 100 μm, which length enables intracellular electrical measurement and DNA introduction into cell for thick biological tissues including brain slice and brain in vivo. In order to realize the > 100-μm-long nanoneedle devices, we have proposed the nanoscale-tipped silicon microneedle device by sharping the tip portion of the silicon microneedle, which can be vertically assembled on a silicon substrate by gold-catalyzed selective vapor-liquid-solid (VLS) crystal growth of silicon. The fabrication process is based on the silicon growth and subsequent micro/nanofabrication processes. We explored the mechanical and electrical characteristics of the proposed nanoelectrode, and demonstrated the intracellular recording capabilities using mouse’s muscle cells ex vivo and mouse’s brain tissue in vivo.
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Report
(5 results)
Research Products
(83 results)
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[Presentation] In vivo Recordings via Microscale Diameter Neuroprobe Assembled on Flexible Package2015
Author(s)
TEO Dong Sheng, Hirohito Sawahata, Shota Yamagiwa, Airi Moriya, Hideo Oi, Yoriko Ando, Rika Numano, Makoto Ishida, Kowa Koida, Takeshi Kawano
Organizer
Neuroscience 2015
Place of Presentation
Chicago, USA
Year and Date
2015-10-17
Related Report
Int'l Joint Research
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