Creation of implants to influence human body using bioresorbable amorphous calcium phosphate films

• Project/Area Number: 26709049
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Composite materials/Surface and interface engineering
• Research Institution: Tohoku University
• Principal Investigator: Ueda Kyosuke 東北大学, 工学(系)研究科(研究院), 准教授 (40507901)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000); Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2015: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000); Fiscal Year 2014: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
• Keywords: 生体材料 / 材料加工・処理 / 非晶質リン酸カルシウム / コーティング / 抗菌性 / 硬組織適合性 / 骨形成タンパク質 / 薬剤徐放 / リン酸カルシウム

Outline of Final Research Achievements

Amorphous calcium phosphate (ACP) film known as bioresorbable material was focused on the surface modification of bone substitutes to improve the bone compatibility. Controlling the bioresorbability and giving the antibacterial activity to the ACP film were conducted by addition of elements and Ag, respectively. Nb and Ta addition to ACP film suppressed the bioresorbability of ACP film. Ag added ACP film showed antibacterial activity against E. coli and S. aureus.

Research Products

• [Journal Article] 抗菌性をもつ生体材料開発 (2017)
  • Author(s): 上田恭介, 成島尚之
  • Journal Title: 炎症と免疫 Volume: 25[2] Pages: 110-117
• [Journal Article] In vitro evaluation of Ag-containing calcium phosphates: Effectiveness of Ag-incorporated β-tricalcium phosphate (2017)
  • Author(s): O. Gokcekaya, K. Ueda, K. Ogasawara, H. Kanetaka, T. Narushima
  • Journal Title: Mater. Sci. Eng. C Volume: 75 Pages: 926-933
  • DOI: 10.1016/j.msec.2017.02.059
  • Peer Reviewed / Open Access
• [Journal Article] In vitro performance of Ag-incorporated hydroxyapatite and its adhesive porous coatings deposited by electrostatic spraying (2017)
  • Author(s): Ozkan Gokcekaya, Thomas J. Webster, Kyosuke Ueda, Takayuki Narushima, Celaletdin Ergun
  • Journal Title: Mater. Sci. Eng. C Volume: 75 Pages: 556-564
  • DOI: 10.1016/j.msec.2017.03.233
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] TiO2 layers on Ti-Au alloy formed by two-step thermal oxidation and their photocatalytic activity in visible-light (2016)
  • Author(s): T. Ueda, S. Sado, K. Ueda, T. Narushima
  • Journal Title: Materials Letters Volume: 185 Pages: 290-294
  • DOI: 10.1016/j.matlet.2016.08.066
  • Peer Reviewed
• [Journal Article] Effects of Precipitates and Albumin in Simulated Body Fluids on Pin-on-Disk Wear Behavior of Biomedical Co-Cr-Mo Alloys (2016)
  • Author(s): K. Ueda, M. Kasamatsu, M. Tanno, K. Ueki, J. Geringer, T. Narushima
  • Journal Title: MATERIALS TRANSACTIONS Volume: 57 Issue: 12 Pages: 2054-2059
  • DOI: 10.2320/matertrans.MI201518
  • NAID: 130005284489
  • ISSN: 1345-9678, 1347-5320
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Formation of Porous Layer with Low Ni Content on NiTi Substrate by Dealloying in Metallic Melts (2016)
  • Author(s): K. Ueda, R. Hashimoto, M. Hirohashi, T. Wada, H. Kato, T. Narushima
  • Journal Title: Journal of the Japan Society of Powder and Powder Metallurgy Volume: 63 Issue: 8 Pages: 766-770
  • DOI: 10.2497/jjspm.63.766
  • NAID: 130005253114
  • ISSN: 0532-8799, 1880-9014
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Ceramic coating of Ti and its alloys using dry processes for biomedical applications (2016)
  • Author(s): Ueda T., Kondo N., Sado S., Gokcekaya O., Ueda K., Ogasawara K. and Narushima T.
  • Journal Title: Interface Oral Health Science 2016: Innovative Research on Biosis & Abiosis Intelligent Interface Volume: - Pages: 23-34
  • DOI: 10.1007/978-981-10-1560-1_2
  • ISBN: 9789811015595, 9789811015601
  • Peer Reviewed / Open Access
• [Journal Article] In vitro properties of Ag-containing calcium phosphates (2016)
  • Author(s): O. Gokcekaya, K. Ueda, T. Narushima, K. Ogasawara, H. Kanetaka
  • Journal Title: Advances in Ceramic Armor, Bioceramics, and Porous Materials: Ceramic Engineering and Science Proceedings Volume: 37[4] Pages: 85-93
  • DOI: 10.1002/9781119321682.ch10
  • Peer Reviewed
• [Journal Article] In vitro properties of Ag-containing calcium phosphate (2016)
  • Author(s): O. Gokcekaya, K. Ueda, T. Narushima, K. Ogasawara, H. Kanetaka
  • Journal Title: Proceedings of ICACC Volume: -
  • Peer Reviewed
• [Journal Article] Synthesis and characterization of Ag-containing calcium phosphates with various Ca/P ratios (2015)
  • Author(s): O. Gokcekaya, K. Ueda, T. Narushima, C. Ergun
  • Journal Title: Mater. Sci. Eng. C Volume: 53 Pages: 111-119
  • DOI: 10.1016/j.msec.2015.04.025
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Control of Ag release from Ag-containing calcium phosphates in simulated body fluid (2015)
  • Author(s): O. Gokcekaya, K. Ueda, T. Narushima
  • Journal Title: Ceramics Transactions Volume: 254 Pages: 13-20
  • DOI: 10.1002/9781119190134.ch2
  • Peer Reviewed
• [Journal Article] Microstructure and Mechanical Property of α+β Type Ti-(0~10)mass%V-(0.5~1)mass%O Alloys (2015)
  • Author(s): 上田恭介, 小林達矢, 成島尚之
  • Journal Title: Journal of the Japan Institute of Metals and Materials Volume: 80 Issue: 1 Pages: 60-65
  • DOI: 10.2320/jinstmet.JB201503
  • NAID: 130005115557
  • ISSN: 0021-4876, 1880-6880, 2433-7501
  • Peer Reviewed
• [Journal Article] In vitro evaluation of Ag-containing calcium phosphates (2015)
  • Author(s): O. Gokcekaya, K. Ueda, T. Narushima, K. Ogasawara
  • Journal Title: Proceedings of the 24th International Symposium on Processing and Fabrication of Advanced Materials, PFAM XXIV Volume: - Pages: 95-103
  • Peer Reviewed
• [Journal Article] 二段階熱酸化プロセスを利用した生体用チタン合金の表面処理 (2014)
  • Author(s): 成島尚之、上田恭介、佐渡翔太
  • Journal Title: 第181回腐食防食シンポジウム: 金属生体材料の腐食・劣化の現状とその対応 Volume: 該当なし Pages: 46-55
  • Peer Reviewed
• [Presentation] Visible-light driven photocatalytic and antibacterial properties of TiO2 layers formed on Ti-Au alloys (2017)
  • Author(s): T. Ueda, S. Sado, K. Ueda, K. Ito, K. Ogasawara, T. Mokudai, H. Kanetaka, Y. Niwano, T. Narushima
  • Organizer: 2017 Japan-Russia Joint Seminar “Advanced Material Synthesis Process and Nanostructure
  • Place of Presentation: Akiu, Sendai
  • Year and Date: 2017-03-21
  • Int'l Joint Research
• [Presentation] Ti-5Al-2Sn-2Zr-4Mo-4Cr (Ti-17)合金の大気中酸化挙動に及ぼすSi添加の影響 (2017)
  • Author(s): 鈴木聡、上田恭介、S.K. Bhattacharya、佐原亮二、北嶋具教、成島尚之
  • Organizer: 日本金属学会第160回大会(2017年春期)
  • Place of Presentation: 首都大学東京, 八王子市
  • Year and Date: 2017-03-15
• [Presentation] α＋β型Ti-4V-0.6O合金の機械的特性に及ぼす熱処理の影響 (2017)
  • Author(s): 大宮正仁、上田恭介、成島尚之
  • Organizer: 日本金属学会第160回大会(2017年春期)
  • Place of Presentation: 首都大学東京, 八王子市
  • Year and Date: 2017-03-15
• [Presentation] 元素添加非晶質リン酸カルシウム膜の構造と溶解性 (2017)
  • Author(s): 上田恭介、永田彪、小幡亜希子、春日敏宏、成島尚之
  • Organizer: 日本金属学会第160回大会(2017年春期)
  • Place of Presentation: 首都大学東京, 八王子市
  • Year and Date: 2017-03-15
• [Presentation] Ti上に作製されたAg含有非晶質リン酸カルシウム膜の評価 (2017)
  • Author(s): 井上紅花、上田恭介、O. Gokcekaya、伊藤甲雄、小笠原康悦、成島尚之
  • Organizer: 日本金属学会第160回大会(2017年春期)
  • Place of Presentation: 首都大学東京, 八王子市
  • Year and Date: 2017-03-15
• [Presentation] 熱酸化法によりTi-Au合金上に作製した可視光応答型TiO2膜の抗菌性評価 (2017)
  • Author(s): 上田隆統志、佐渡翔太、上田恭介、伊藤甲雄、小笠原康悦、成島尚之
  • Organizer: 日本金属学会第160回大会(2017年春期)
  • Place of Presentation: 首都大学東京, 八王子市
  • Year and Date: 2017-03-15
• [Presentation] Ti合金上に作製した可視光応答型光触媒TiO2膜による抗菌性発現 (2017)
  • Author(s): 上田隆統志、佐渡翔太、上田恭介、成島尚之、小笠原康悦、伊藤甲雄、金高弘恭、目代貴之、庭野吉己
  • Organizer: 学際・国際的高度人材育成ライフイノベーションマテリアル創製共同研究プロジェクト 平成28年度第1回公開討論会
  • Place of Presentation: 名古屋大学, 名古屋市
• [Presentation] Ti-6Al-4V-xSi （x＝0～1mass%）合金の耐酸化性と機械的特性 (2016)
  • Author(s): 前田幸大、上田恭介、北嶋具教、池田亜矢子、萩原益夫、佐原亮二、御手洗容子、成島尚之
  • Organizer: 日本金属学会第159回大会(2016年秋期)
  • Place of Presentation: 大阪大学, 豊中市
  • Year and Date: 2016-09-21
• [Presentation] 熱酸化法を用いたTi-Au合金表面へのTiO2皮膜の作製および可視光応答型光触媒活性評価 (2016)
  • Author(s): 上田隆統志、佐渡翔太、上田恭介、成島尚之
  • Organizer: 日本金属学会第159回大会(2016年秋期)
  • Place of Presentation: 大阪大学, 豊中市
  • Year and Date: 2016-09-21
• [Presentation] Formation and elution of element-added amorphous calcium phosphate films (2016)
  • Author(s): T. Nagata, K. Ueda, A. Obata, T. Kasuga, T. Goto, T. Narushima
  • Organizer: The 11th International Workshop on Biomaterials in Interface Science
  • Place of Presentation: Tohoku Univ., Sendai
  • Year and Date: 2016-08-30
  • Int'l Joint Research
• [Presentation] Photocatalytic evaluation of thermally-oxidized titania layers formed on Ti-Au alloys (2016)
  • Author(s): T. Ueda, S. Sado, K. Ueda, T. Narushima
  • Organizer: The 11th International Workshop on Biomaterials in Interface Science
  • Place of Presentation: Tohoku Univ., Sendai
  • Year and Date: 2016-08-29
  • Int'l Joint Research
• [Presentation] Fabrication of a bioresorbable Ag-containing amorphous calcium phosphate coating film and evaluation of its antibacterial activity (2016)
  • Author(s): K. Ueda, N. Kondo, O. Gokcekaya, T. Kasuga, A. Obata, K. Ogasawara, H. Kanetaka, T. Narushima
  • Organizer: The 9th Pacific Rim International Conference on Advanced Materials and Processing (PRICM9)
  • Place of Presentation: Kyoto International Conference Center, Kyoto
  • Year and Date: 2016-08-01
  • Int'l Joint Research
• [Presentation] Effect of elemental addition on bioresorbability of amorphous calcium phosphate film fabricated by RF magnetron sputtering (2016)
  • Author(s): T. Nagata, K. Ueda, T. Kasuga, A. Obata, T. Narushima
  • Organizer: The 9th Pacific Rim International Conference on Advanced Materials and Processing (PRICM9)
  • Place of Presentation: Kyoto International Conference Center, Kyoto
  • Year and Date: 2016-08-01
  • Int'l Joint Research
• [Presentation] In vitro dissolution behavior and antibacterial activity of Ag-containing biphasic calcium phosphates (2016)
  • Author(s): O. Gokcekaya, K. Ueda, T. Narushima, K. Ogasawara, H. Kanetaka
  • Organizer: The 9th Pacific Rim International Conference on Advanced Materials and Processing (PRICM9)
  • Place of Presentation: Kyoto International Conference Center, Kyoto
  • Year and Date: 2016-08-01
  • Int'l Joint Research
• [Presentation] Effect of chemical state of silver added to calcium phosphates on dissolution behavior, antibacterial activity, and cytotoxicity (2016)
  • Author(s): K. Ueda, O. Gokcekaya, K. Ogasawara, H. Kanetaka, T. Narushima
  • Organizer: International Conference on Processing & Manufacturing of Advanced Materials (THERMEC’ 2016)
  • Place of Presentation: Gras, Austria
  • Year and Date: 2016-05-29
  • Int'l Joint Research / Invited
• [Presentation] Ti-6Al-4V合金の耐酸化性に及ぼすSi添加の影響 (2016)
  • Author(s): 前田幸大、上田恭介、成島尚之
  • Organizer: 軽金属学会第130回春期大会
  • Place of Presentation: 大阪大学, 吹田市
  • Year and Date: 2016-05-28
• [Presentation] TiへのAg含有非晶質リン酸カルシウム薄膜の作製とその抗菌性評価 (2016)
  • Author(s): 上田恭介、近藤なつ美、O. Gokcekaya、小幡亜希子、春日敏宏、小笠原康悦、成島尚之
  • Organizer: 軽金属学会第130回春期大会
  • Place of Presentation: 大阪大学, 吹田市
  • Year and Date: 2016-05-28
• [Presentation] Fabrication and evaluation of Nb-containing amorphous calcium phosphate coating film on Ti (2016)
  • Author(s): K. Ueda, A. Obata, T. Kasuga, T. Goto, K. Ogasawara, T. Narushima
  • Organizer: 10th World Biomaterials Congress (WBC2016)
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2016-05-17
  • Int'l Joint Research
• [Presentation] RFマグネトロンスパッタリング法によるAg含有非晶質リン酸カルシウム薄膜の作製とその評価 (2016)
  • Author(s): 上田恭介、近藤なつ美、小幡亜希子、春日敏宏、小笠原康悦、成島尚之
  • Organizer: 日本金属学会 第158回大会
  • Place of Presentation: 東京, 東京理科大学葛飾キャンパス
  • Year and Date: 2016-03-25
• [Presentation] 元素添加による非晶質リン酸カルシウム薄膜の生体吸収性制御 (2016)
  • Author(s): 永田彪、上田恭介、小幡亜希子、春日敏宏、成島尚之
  • Organizer: 日本金属学会 第158回大会
  • Place of Presentation: 東京, 東京理科大学葛飾キャンパス
  • Year and Date: 2016-03-25
• [Presentation] In vitro properties of Ag-containing calcium phosphates (2016)
  • Author(s): O. Gokcekaya, K. Ueda, T. Narushima, K. Ogasawara, H. Kanetaka
  • Organizer: 40th International Conference and Expo on Advanced Ceramics and Composites, ICACC16
  • Place of Presentation: Florida, USA
  • Year and Date: 2016-01-29
  • Int'l Joint Research
• [Presentation] 元素添加による生体吸収性非晶質リン酸カルシウム薄膜の生体適合性向上 (2016)
  • Author(s): 上田恭介、小幡亜希子、春日敏宏、小笠原康悦、成島尚之
  • Organizer: 東北大学金属材料研究所共同研究ワークショップ・日本バイオマテリアル学会東北地域講演会「バイオマテリアル研究 若手交流会」
  • Place of Presentation: 東北大学, 仙台市
• [Presentation] Ti-17合金の耐酸化性に及ぼすSi添加の影響 (2016)
  • Author(s): 上田恭介、鈴木聡、成島尚之
  • Organizer: 第4回チタン若手交流会
  • Place of Presentation: 新日鐵住金, 直江津市
• [Presentation] In vitro evaluation of Ag-containing calcium phosphates (2015)
  • Author(s): O. Gokcekaya, K. Ueda, T. Narushima, K. Ogasawara, H. Kanetaka
  • Organizer: 24th International Symposium on Processing and Fabrication of Advanced Materials, PFAM XXIV
  • Place of Presentation: Osaka, Janan, Kansai University
  • Year and Date: 2015-12-20
  • Int'l Joint Research
• [Presentation] Antibacterial activity and cytotoxicity of Ag-containing calcium phosphates (2015)
  • Author(s): Ozkan Gokcekaya、上田恭介、成島尚之、小笠原康悦、金髙弘恭
  • Organizer: 日本金属学会 第157回大会
  • Place of Presentation: 福岡, 九州大学伊都キャンパス
  • Year and Date: 2015-09-17
• [Presentation] Evaluation of antibacterial activity of Ag-containing calcium phosphates (2015)
  • Author(s): K. Ueda, O. Gokcekaya, T. Narushima, K. Ogasawara, H. Kanetaka
  • Organizer: The 10th Anniversary International Workshop on Biomaterials in Interface Science
  • Place of Presentation: Zao, Japan, バーデン家壮鳳
  • Year and Date: 2015-08-04
  • Int'l Joint Research
• [Presentation] Control of bioresorbability of amorphous calcium phosphate coating film with niobium added (2015)
  • Author(s): K. Ueda, T. Takahashi, A. Obata, T. Kasuga, T. Goto, T. Narushima
  • Organizer: Biomaterials International 2015
  • Place of Presentation: Kenting, Taiwan
  • Year and Date: 2015-06-02
  • Int'l Joint Research
• [Presentation] Ag含有リン酸カルシウムの抗菌性評価 (2015)
  • Author(s): 上田恭介、関山雅人、Ozkan Gokcekaya、成島尚之、小笠原康悦
  • Organizer: 粉体粉末冶金協会平成27年度春季大会
  • Place of Presentation: 東京, 早稲田大学
  • Year and Date: 2015-05-27
• [Presentation] Ti上へのAg添加非晶質リン酸カルシウム薄膜の作製 (2015)
  • Author(s): 近藤なつ美、上田恭介、成島尚之
  • Organizer: 軽金属学会第128回春期大会
  • Place of Presentation: 仙台, 東北大学青葉山キャンパス
  • Year and Date: 2015-05-16
• [Presentation] ドライプロセスによるチタンの骨適合化表面改質 (2015)
  • Author(s): 上田恭介、成島尚之、後藤孝、小幡亜希子、春日敏宏、小笠原康悦
  • Organizer: 日本金属学会2015年春期
  • Place of Presentation: 東京大学（東京都）
  • Year and Date: 2015-03-20
  • Invited
• [Presentation] 二段階熱酸化法によりTi-AgおよびTi-Au合金表面に作製されたTiO2皮膜の可視光照射下における光触媒活性評価 (2015)
  • Author(s): 上田隆統志、佐渡翔太、上田恭介、成島尚之
  • Organizer: 日本金属学会 第156回大会(2015年春期)
  • Place of Presentation: 東京大学（東京都）
  • Year and Date: 2015-03-19
• [Presentation] MgO/CaOを多量に含有するリン酸塩インバートガラスの作製 (2015)
  • Author(s): 李誠鎬、前田浩孝、小幡亜希子、上田恭介、成島尚之、春日敏宏
  • Organizer: 日本金属学会 第156回大会(2015年春期)
  • Place of Presentation: 東京大学（東京都）
  • Year and Date: 2015-03-18
• [Presentation] Biomaterials: Metallic materials in the human body (2015)
  • Author(s): K. Ueda
  • Organizer: 13th Tohoku Univ. & Univ. Sci. Technol. Beijing exchange program
  • Place of Presentation: 北京科技大学（中国）
  • Year and Date: 2015-03-06
• [Presentation] 生体吸収性リン酸カルシウムによるインプラントの骨適合性向上 (2015)
  • Author(s): 上田恭介、成島尚之、後藤孝、小幡亜希子、春日敏宏、小笠原康悦
  • Organizer: 日本材料学会 第38回生体・医療材料部門委員会
  • Place of Presentation: 東北大学（宮城県・仙台市）
  • Year and Date: 2015-01-20
  • Invited
• [Presentation] Effect of Ag2O substitution on solubility and structure of CaO-P2O5-Nb2O5 glasses (2014)
  • Author(s): S. Lee, H. Maeda, A. Obata, K. Ueda, T. Narushima, T. Kasuga
  • Organizer: The 31st International Korea-Japan Seminar on Ceramics
  • Place of Presentation: 昌原市（韓国）
  • Year and Date: 2014-11-27
• [Presentation] 高酸素濃度含有チタン合金の組織と特性 (2014)
  • Author(s): 上田恭介、小林達矢、成島尚之
  • Organizer: 軽金属学会第127回秋期大会
  • Place of Presentation: 東京工業大学（東京都）
  • Year and Date: 2014-11-15
• [Presentation] Preparation of antibacterial phosphate invert glasses (2014)
  • Author(s): S. Lee, H. Maeda, A. Obata, K. Ueda, T. Narushima, T. Kasuga
  • Organizer: 26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine (Bioceramics26)
  • Place of Presentation: バルセロナ（スペイン）
  • Year and Date: 2014-11-07
• [Presentation] 金属系バイオマテリアルの骨適合化表面処理 (2014)
  • Author(s): 上田 恭介
  • Organizer: (一社)表面技術協会 関東支部 第88回講演会
  • Place of Presentation: 東京医科歯科大学（東京都）
  • Year and Date: 2014-10-24
  • Invited
• [Presentation] Control of Ag release from Ag-containing calcium phosphates in simulated body fluid (2014)
  • Author(s): O. Gokcekaya, K. Ueda, T. Narushima
  • Organizer: Materials Science & Technology 2014 (MS&T14)
  • Place of Presentation: ピッツバーグ（アメリカ）
  • Year and Date: 2014-10-16
• [Presentation] Preparation of calcium pyrophosphate glasses (2014)
  • Author(s): S. Lee, H. Maeda, A. Obata, K. Ueda, T. Narushima, T. Kasuga
  • Organizer: 6th International Workshop on Advanced Ceramics
  • Place of Presentation: ニュルンベルク（ドイツ）
  • Year and Date: 2014-09-30
• [Presentation] 熱酸化法によりTi上に作製したTiO2皮膜特性に及ぼすNbの影響 (2014)
  • Author(s): 佐渡翔太、徳田洋介、上田恭介、成島尚之
  • Organizer: 日本金属学会 第155回大会(2014年秋期)
  • Place of Presentation: 名古屋大学（愛知県・名古屋市）
  • Year and Date: 2014-09-25
• [Presentation] 熱酸化法によりTi上に作製したTiO2皮膜の光触媒活性による抗菌性評価 (2014)
  • Author(s): 近藤なつ美、佐渡翔太、上田恭介、成島尚之、小笠原康悦
  • Organizer: 日本金属学会 第155回大会(2014年秋期)
  • Place of Presentation: 名古屋大学（愛知県・名古屋市）
  • Year and Date: 2014-09-24
• [Presentation] カルシウム成分を多量に含有するリン酸塩ガラスの作製 (2014)
  • Author(s): 李誠鎬、前田浩孝、小幡亜希子、上田恭介、成島尚之、春日敏宏
  • Organizer: 日本金属学会 第155回大会(2014年秋期)
  • Place of Presentation: 名古屋大学（愛知県・名古屋市）
  • Year and Date: 2014-09-24
• [Presentation] 高酸素濃度含有チタン合金の組織および特性評価 (2014)
  • Author(s): 小林達矢、上田恭介、成島尚之
  • Organizer: 日本金属学会 第155回大会(2014年秋期)
  • Place of Presentation: 名古屋大学（愛知県・名古屋市）
  • Year and Date: 2014-09-24
• [Presentation] 二段階熱酸化プロセスを利用した生体用チタンの表面処理 (2014)
  • Author(s): 成島尚之、佐渡翔太、近藤なつ美、上田恭介
  • Organizer: 第181回腐食防食シンポジウム
  • Place of Presentation: 東京医科歯科大学（東京都）
  • Year and Date: 2014-09-16
• [Presentation] Evaluation of TiO2 layer formed on Ti-Nb alloys by thermal oxidation (2014)
  • Author(s): K. Ueda, Y. Tokuda, S. Sado, T. Narushima
  • Organizer: 9th International Workshop on Biomaterials in Interface Scinece
  • Place of Presentation: 蔵王ロイヤルホテル（宮城県・蔵王町）
  • Year and Date: 2014-08-27
• [Book] 歯科再生・修復医療と材料 (2015)
  • Author(s): 成島尚之、上田恭介、上田隆統志、佐渡翔太(他42名)
  • Total Pages: 269
  • Publisher: シーエムシー出版
• [Book] バイオマテリアル研究の最前線 (2014)
  • Author(s): 成島尚之、中野貴由
  • Total Pages: 250
  • Publisher: 日本金属学会編集
• [Patent(Industrial Property Rights)] 光触媒機能性部材およびその製造方法 (2017)
  • Inventor(s): 成島尚之、上田恭介、上田隆統志、佐渡翔太、小笠原康悦、他
  • Industrial Property Rights Holder: 成島尚之、上田恭介、上田隆統志、佐渡翔太、小笠原康悦、他
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2017-036719
  • Filing Date: 2017-02-28
• [Patent(Industrial Property Rights)] 耐熱Ti合金および耐熱Ti合金材 (2016)
  • Inventor(s): 成島尚之、上田恭介、前田幸大、鈴木聡
  • Industrial Property Rights Holder: 成島尚之、上田恭介、前田幸大、鈴木聡
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-105199
  • Filing Date: 2016-05-26