| Budget Amount *help |
¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2014: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
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| Outline of Final Research Achievements |
MRI-guided magnetic thermochemotherapy is a potentially invasive technique combining diagnosis and treatment. It requires the development of multifunctional nanoparticles with: 1) biocompatibility; 2) high relaxivity; 3) high heat-generation power; 4) controlled drug release; and 5) tumor targeting. In this study, we synthesized such multifunctional nanoparticles ("Core-Shells"). "Tight" iron-oxide nanoparticle clustering to zero interparticle distance within the Core-Shells boosts the relaxivity and heat-generation power while maintaining biocompatibility. A single Core-Shell dose realizes continuous chemotherapy over a period of days. The Core-Shells accumulate in abdomen tumors, facilitating MRI visualization. Subsequent an alternating magnetic field (AMF) application induces heat generation and drug release within the tumors. Core-Shell magnetic thermochemotherapy exhibits significantly higher therapeutic efficacy than both magnetic hyperthermia and chemotherapy alone.
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