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Role of dopamine signals in prefrontal executive functions

Research Project

Project/Area Number 26710001
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Neurophysiology / General neuroscience
Research InstitutionUniversity of Tsukuba

Principal Investigator

Matsumoto Masayuki  筑波大学, 医学医療系, 教授 (50577864)

Co-Investigator(Renkei-kenkyūsha) INOUE Ken-ichi  京都大学, 霊長類研究所, 助教 (90455395)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywordsドーパミンニューロン / 行動抑制 / 尾状核 / 前頭前野 / ドーパミン / response inhibition / ドーパミン受容体拮抗薬
Outline of Final Research Achievements

Although dopamine neurons are well known as key components of the brain’s reward system, the degeneration of these neurons causes not only reward-related motivational dysfunctions but also motor and cognitive dysfunctions as seen in Parkinson’s disease. In the present study, we focused on a cognitive function called “response inhibition”, which is required to inhibit inappropriate actions, and found that the nigrostriatal dopamine pathway plays a crucial role in response inhibition in macaque monkeys. Furthermore, we were able to develop a new optogenetic technique that can stimulate targeted neural pathways in the macaque brain. We are planning to stimulate the nigrostriatal dopamine pathway using this optogenetic technique and examine whether stimulating this pathway enhances the performance of response inhibition.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (21 results)

All 2018 2017 2016 2015 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Int'l Joint Research: 9 results,  Invited: 5 results) Remarks (3 results)

  • [Journal Article] Preferential representation of past outcome information and future choice behavior by putative inhibitory interneurons rather than putative pyramidal neurons in the primate dorsal anterior cingulate cortex2018

    • Author(s)
      Takashi Kawai, Hiroshi Yamada, Nobuya Sato, Masahiko Takada, Masayuki Matsumoto
    • Journal Title

      Cerebral Cortex

      Volume: 印刷中 Issue: 6 Pages: 2339-2352

    • DOI

      10.1093/cercor/bhy103

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple Dopamine Signals and Their Contributions to Reinforcement Learning2016

    • Author(s)
      Matsumoto M
    • Journal Title

      BRAIN and NERVE

      Volume: 68 Issue: 10 Pages: 1139-1147

    • DOI

      10.11477/mf.1416200567

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2016-10-01
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal and behavioral modulations by pathway-selective optogenetic stimulation of the primate oculomotor system.2015

    • Author(s)
      Inoue K, Takada M, Matsumoto M
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 8378-8378

    • DOI

      10.1038/ncomms9378

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 「嫌な出来事を避ける」ための神経基盤:外側手綱核と前部帯状皮質の役割2015

    • Author(s)
      川合 隆嗣, 山田 洋, 佐藤 暢哉, 高田 昌彦, 松本 正幸
    • Journal Title

      生体の科学

      Volume: 66 Pages: 24-28

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Dopamine signals and physiological origin of cognitive dysfunction in Parkinson's disease.2015

    • Author(s)
      Masayuki Matsumoto
    • Journal Title

      Movement Disorders

      Volume: 30 Issue: 4 Pages: 472-83

    • DOI

      10.1002/mds.26177

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Role of the nigrostriatal dopamine system in response inhibition2018

    • Author(s)
      Matsumoto Masayuki
    • Organizer
      The 95th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Multiple signals transmitted by midbrain dopamine neurons2017

    • Author(s)
      Matsumoto M
    • Organizer
      日本生理学会
    • Place of Presentation
      浜松アクトシティコングレスセンター 静岡県浜松市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 認知機能と報酬機能を支えるドーパミン神経系の生理学的基盤2017

    • Author(s)
      松本正幸
    • Organizer
      日本統合失調症学会
    • Place of Presentation
      米子コンベンションセンター 鳥取県米子市
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Primate dopamine neurons in the substantia nigra transmit a stop signal to the caudate nucleus during the performance of a saccadic countermanding task2017

    • Author(s)
      Ogasawara Takaya, Takada Masahiko, Matsumoto Masayuki
    • Organizer
      The 40th annual meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nigrostriatal dopamine signals regulate response inhibition2017

    • Author(s)
      Matsumoto Masayuki
    • Organizer
      The 40th annual meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 黒質-線条体ドーパミン神経路が行動抑制に果たす役割2017

    • Author(s)
      松本正幸
    • Organizer
      第39回日本生物学的精神医学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Nigrostriatal dopamine pathway transmit a stop signal during the performance of a saccadic countermanding task in monkeys2017

    • Author(s)
      Ogasawara Takaya, Takada Masahiko, Matsumoto Masayuki
    • Organizer
      Society for Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nigrostriatal signal inhibits saccadic eye movement during countermanding task in monkeys2016

    • Author(s)
      Ogasawara T, Takada M, Matsumoto M
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optogenetic stimulation of the pathway from the frontal eye field to the superior colliculus evokes neuronal and behavioral modulations in monkeys2015

    • Author(s)
      Ken-ichi Inoue, Masahiko Takada, Masayuki Matsumoto
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Chicago (USA)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Outcome monitoring and behavioral adjustment by putative pyramidal neurons and interneurons in the primate anterior cingulate cortex during a reversal learning task2015

    • Author(s)
      T. KAWAI, H. YAMADA, N. SATO, M. TAKADA, M. MATSUMOTO
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Chicago (USA)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Midbrain dopamine neurons signal whether planned eye movements are successfully cancelled during a saccadic stop-signal task2015

    • Author(s)
      T. OGASAWARA, M. TAKADA, M. MATSUMOTO
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Chicago (USA)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Oculomotor manipulations by pathway-selective optogenetics in non-human primates2015

    • Author(s)
      Ken-ichi Inoue, Maki Fujiwara, Ryuji Yasukouchi, Kiyomi Nagaya, Masahiko Takada, Masayuki Matsumoto
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸、神戸国際会議場
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Role of dopamine signals in response inhibition2015

    • Author(s)
      T. OGASAWARA, M. TAKADA, M. MATSUMOTO
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸、神戸国際会議場
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Remarks] 筑波大学医学医療系認知行動神経科学

    • URL

      http://www.md.tsukuba.ac.jp/basic-med/cog-neurosci/index.html

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Remarks] 筑波大学医学医療系認知行動神経科学

    • URL

      http://www.md.tsukuba.ac.jp/basic-med/cog-neurosci/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 筑波大学 医学医療系 生命医科学域 認知行動神経科学研究室

    • URL

      http://www.md.tsukuba.ac.jp/basic-med/cog-neurosci/

    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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