| Budget Amount *help |
¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
|
|---|
| Outline of Final Research Achievements |
Orientation preference among clonally-related cells from same cell-lineage is more similar than among unrelated cells in the rodents’ primary visual cortex. While the similarity of orientation selectivity among the clonally-related neurons is moderate in adult mice, it could be stronger at immature stage with less visual experiences. Here, by using the combination of in vivo two-photon Ca2+ imaging and a cell-lineage tracing with transgenic mice, we examined visual responses of clonally-related neurons, progeny derived from a single cortical progenitor cell, in the course of maturation from eye opening to mature state. We found that while clonally-related cells are more similar in orientation preference through development, the functional similarity was higher in juvenile. Comparison of the similarity in vertically aligned cells revealed the functional similarity in narrower column is especially high in younger cortex.
|
