| Budget Amount *help |
¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
A combination method of fecal occult blood test (FOBT) and fecal miRNA test (FmiRT) was examined for colorectal cancer screening. Fecal miRNA could be extracted from the FOBT residua, and both the relative quantification method and the absolute quantification method for miRNA expression could be established in this study. Among 90 patients with advanced neoplasia and 60 healthy subjects, the sensitivity and specificity of FOBT were 74.4% and 93.3%, and the sensitivity and specificity of the combination method of FOBT and FmiRT were 93.3% and 91.7%. The combination of FOBT and FmiRT might be useful for colorectal cancer screening.
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