| Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2016: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2014: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Outline of Final Research Achievements |
More than 45% of human genome consists of transposons and its remnants. Transpositional events of them are deleterious to their hosts, especially in their gonads. Here, I am engaged in how small RNA would induce transcriptional silencing at transposon sequences, by using both fly and mouse systems. For fly system, I am trying to establish a method to proteomically identify the chromatin components at specific genomic region. For mouse system, I have profiled the chromatin dynamics in the small number of germ cells within the whole testis, and comprehensively described its temporal change in detail, particularly at transposon sequences.
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