Molecular mechanisms of piRNA biogenesis
| Project/Area Number |
26711006
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Keio University |
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Principal Investigator |
Saito Kuniaki 慶應義塾大学, 医学部, 准教授 (30423396)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
Fiscal Year 2015: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2014: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
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| Keywords | 発現制御 / 遺伝子 / RNA / プロセシング / 輸送 |
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| Outline of Final Research Achievements |
In Drosophila ovarian somatic cells (OSCs), we discovered a cytoplasmic granular body named as flam body, where piRNA precursors accumulate (Murota et al. Cell Reports 2014). flam body is closely localized and partially overlapped with Yb body. Disruption of Yb expression in OSCs abolished flam body signals, suggesting that flam body and Yb body are interacted with each other in the process of piRNA biogenesis.
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Report
(3 results)
Research Products
(2 results)
