Molecular mechanisms of piRNA biogenesis

Research Project

Project/Area Number	26711006
Research Category	Grant-in-Aid for Young Scientists (A)
Allocation Type	Partial Multi-year Fund
Research Field	Functional biochemistry
Research Institution	Keio University
Principal Investigator	Saito Kuniaki 慶應義塾大学, 医学部, 准教授 (30423396)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000) Fiscal Year 2015: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000) Fiscal Year 2014: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Keywords	発現制御 / 遺伝子 / RNA / プロセシング / 輸送
Outline of Final Research Achievements	In Drosophila ovarian somatic cells (OSCs), we discovered a cytoplasmic granular body named as flam body, where piRNA precursors accumulate (Murota et al. Cell Reports 2014). flam body is closely localized and partially overlapped with Yb body. Disruption of Yb expression in OSCs abolished flam body signals, suggesting that flam body and Yb body are interacted with each other in the process of piRNA biogenesis.