Regulation of body growth and metabolism through nutritional signal
Project/Area Number |
26711007
|
Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Functional biochemistry
|
Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
Nishimura Takashi 国立研究開発法人理化学研究所, 多細胞システム形成研究センター, チームリーダー (90568099)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2014: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
|
Keywords | インスリン / インスリン様成長因子 / 成長制御 / 代謝調節 / ショウジョウバエ / 生理学 / 遺伝学 / シグナル伝達 |
Outline of Final Research Achievements |
Insulin/insulin-like growth factor (IGF) signaling plays an important role in the regulation of biological processes such as growth, metabolism, reproduction and longevity, and is known to be widely conserved across species. In mammals, major players of this pathway are insulin and IGF, which have distinct roles in metabolism and growth, respectively, whereas in the Drosophila fruit fly, there are eight insulin-like peptides (Dilps) that fulfill these roles. The function and regulation of these endocrine hormones must be capable of readily adapting to environmental changes, particularly to nutrient availability. Our work revealed a complex signaling relay and positive feedback mechanism at work to control the expression of dilp5 in the insulin-producing cells of the fly brain. These results provide a molecular framework that explains how the production of an endocrine hormone in a specific tissue is coordinated with environmental conditions.
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Report
(4 results)
Research Products
(19 results)