| Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2014: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Outline of Final Research Achievements |
Insulin/insulin-like growth factor (IGF) signaling plays an important role in the regulation of biological processes such as growth, metabolism, reproduction and longevity, and is known to be widely conserved across species. In mammals, major players of this pathway are insulin and IGF, which have distinct roles in metabolism and growth, respectively, whereas in the Drosophila fruit fly, there are eight insulin-like peptides (Dilps) that fulfill these roles. The function and regulation of these endocrine hormones must be capable of readily adapting to environmental changes, particularly to nutrient availability. Our work revealed a complex signaling relay and positive feedback mechanism at work to control the expression of dilp5 in the insulin-producing cells of the fly brain. These results provide a molecular framework that explains how the production of an endocrine hormone in a specific tissue is coordinated with environmental conditions.
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