Microtubule generation independent of centrosomes
| Project/Area Number |
26711012
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Nagoya University |
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Principal Investigator |
Goshima Gohta 名古屋大学, 理学研究科, 教授 (20447840)
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| Research Collaborator |
WATANABE Sadanori
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2016: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2015: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2014: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | 微小管 / オーグミン / 微小管生成 / 微小管増幅 / ノックアウトマウス |
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| Outline of Final Research Achievements |
This research project aimed to understand the mechanism of centrosome-independent microtubule generation. The major outcomes are as follows: (1) The augmin complex has been shown required for centrosome-independent microtubule nucleation within the mitotic spindle in animal and plant cells. Here, we identified augmin in the filamentous fungus, elucidating the evolutionary conservation of this protein complex. (2) We generated knockout mice of a critical augmin subunit, and identified a defect in MTOC clustering during early embryonic division. (3) Microtubule nucleation independent of centrosomes or augmin was identified in the moss Physcomitrella patens.
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Report
(5 results)
Research Products
(24 results)
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[Journal Article] Augmin shapes the anaphase spindle for efficient cytokinetic furrow ingression and abscission.2016
Author(s)
Uehara, R., Kamasaki, T., Hiruma, S., Poser, I., Yoda, K., Yajima, J., Gerlich, D.W., and Goshima, G.
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Journal Title
Molecular Biology of the Cell
Volume: 27
Issue: 5
Pages: 812-827
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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