| Budget Amount *help |
¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2016: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Outline of Final Research Achievements |
This study aims for identification of nerve molecules, which regulate blastema induction phase in amphibian limb regeneration. It has been well described that nerve plays an essential roles in blastema induction. However, identification of nerve factors had not been achieved over 190 years. We approached this issue with a brand-new experimental model called the accessory limb model, which we established recently. What we found in this study was that Fibroblast growth factors (Fgfs) and Bone morphogenic protein (Bmp) could substitute for nerve roles in blastema induction. Moreover, we demonstrated that our defined molecules can induce organ-level regeneration in multiple organs and species.
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