Determination of regeneration inducers in urodele amphibians
| Project/Area Number |
26711015
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Okayama University |
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Principal Investigator |
satoh akira 岡山大学, 異分野融合先端研究コア, 准教授 (90512004)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2016: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | 四肢再生 / 過剰肢付加モデル / イモリ / メキシコサラマンダー / 器官再生 / 再生因子 / 神経 / 脱分化 |
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| Outline of Final Research Achievements |
This study aims for identification of nerve molecules, which regulate blastema induction phase in amphibian limb regeneration. It has been well described that nerve plays an essential roles in blastema induction. However, identification of nerve factors had not been achieved over 190 years. We approached this issue with a brand-new experimental model called the accessory limb model, which we established recently. What we found in this study was that Fibroblast growth factors (Fgfs) and Bone morphogenic protein (Bmp) could substitute for nerve roles in blastema induction. Moreover, we demonstrated that our defined molecules can induce organ-level regeneration in multiple organs and species.
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Report
(5 results)
Research Products
(12 results)
