| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Outline of Final Research Achievements |
We study the mechanisms for cytokinesis, which is the dynamic process accompanied by the whole cell deformation using fission yeast as a model organism. It has been found that actin polymerization and depolymerization is important at each step in cytokinesis. To elucidate the mechanism for contraction of the contractile ring, I constructed the tool to analyze distribution and orientation of myosin II in a contractile ring by ultrastructural analyses and super resolution microscopies using the cell ghosts or the isolated rings. In addition, we found the special condition for cleavage furrow ingression in the fission yeast spheroplasts in the presence of cell wall-degradative enzymes.
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