Innovation of novel technology in meat quality regulation by agricultural by-products with PPARdelta agonistic activities
Project/Area Number |
26712023
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Animal production science
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Research Institution | Kyushu University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
|
Keywords | 骨格筋 / 筋線維タイプ / 肉質 / PPARδ / 遅筋 / 速筋 / 食肉生産 / ブタ / 豚肉 / 食肉 / 機能性飼料 / 食味性 / ユキレイタケ |
Outline of Final Research Achievements |
Muscles having abundant slow fiber type exhibit good meat quality and tenderness. Activation of peroxisome proliferator-activated receptor (PPAR)delta is thought to induce fast-to-slow fiber type transition. Here, we measured and searched various PPARdelta agonistic activities from various agricultural products and by-products. We found the extracts of both Yukireitake mushroom and the mushroom bed showed potent PPARdelta agonistic activities. The expression level of PPARdelta target genes after the administration of these extracts tended to be up-regulated dose-dependently via interperitoneal injection. Meanwhile, these activities were diminished when orally injected. Thus, to obtain the PPARdelta agonistic activities of Yukireitake mushroom or mushroom bed, it is needed to find a way to avoid the effects of a digestive tract.
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Report
(5 results)
Research Products
(76 results)
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[Journal Article] 食品としての油脂が骨格筋の代謝特性へ与える影響と筋線維タイプとの関連2018
Author(s)
小宮佑介, 丸山アレクサンデル, 渡辺裕介, 内田直愛, 大津翔平, 小林千亜暉, 横山壱成, 鈴木貴弘, 中 村真子, 辰巳隆一, 池内義秀, 水野谷航, 有原圭三
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Journal Title
家畜栄養生理研究会報
Volume: 62
Pages: 9-17
NAID
Related Report
Peer Reviewed
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[Journal Article] Fast-to-slow shift of muscle fiber-type composition by dietary apple polyphenols in rats: Impact of the low-dose supplementation2017
Author(s)
Mizunoya W, Okamoto S, Miyahara H, Akahoshi M, Suzuki T, Do MKQ, Ohtsubo H, Komiya Y, Qahar M, Waga T, Nakazato K, Ikeuchi Y, Anderson JE, Tatsumi R
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Journal Title
Animal Science Journal
Volume: 88
Issue: 3
Pages: 489-499
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Data supporting possible implication of APOBEC2 in self-renewal functions of myogenic stem satellite cells: toward understanding the negative regulation of myoblast differentiation.2017
Author(s)
Ohtsubo, H., Sato Y., Suzuki, T., Mizunoya, W., Nakamura, M., Tatsumi, R., and Ikeuchi, Y.
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Journal Title
Data in Brief
Volume: 12
Pages: 269-273
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Slow-Myofiber Commitment by Semaphorin 3A Secreted from Myogenic Stem Cell2017
Author(s)
R Tatsumi,T Suzuki, Mai-Khoi Q. Do, Y Ohya, JE. Anderson, A Shibata, M Kawaguchi, S Ohya, H Ohtsubo, W Mizunoya, S Sawano, Y Komiya, R Ichitsubo, K Ojima, S Nishimatsu, T Nohno, Y Ohsawa, Y Sunada, M Nakamura, M Furuse, Y Ikeuchi, T Nishimura, T Yagi, and R E. Allen
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Journal Title
STEM CELLS
Volume: 35
Issue: 7
Pages: 1815-1834
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The role of semaphorin 3A in myogenic regeneration and the formation of functional neuromuscular junctions on new fibers.2016
Author(s)
Anderson, JE., Do, M.-K. Q., Daneshvar, N., Suzuki, T., Dort, J., Mizunoya, W., and Tatsumi, R.
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Journal Title
Biological Review
Volume: 92
Issue: 3
Pages: 1389-1405
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Improvement of Endurance Based on Muscle Fiber-Type Composition by Treatment with Dietary Apple Polyphenols in Rats.2015
Author(s)
Mizunoya W, Miyahara H, Okamoto S, Akahoshi M, Suzuki T, Do MK, Ohtsubo H, Komiya Y, Lan M, Waga T, Iwata A, Nakazato K, Ikeuchi Y, Anderson JE, Tatsumi R
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Journal Title
PLoS One.
Volume: 10
Issue: 7
Pages: e0134303-e0134303
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Transmembrane proteoglycans syndecan-2, 4, receptor candidates for the impact of HGF and FGF2 on semaphorin 3A expression in early-differentiated myoblasts2015
Author(s)
Mai-Khoi Q. Do, Naomi Shimizu, Takahiro Suzuki, Hideaki Ohtsubo, Wataru Mizunoya, Mako Nakamura, Shoko Sawano, Mitsuhiro Furuse, Yoshihide Ikeuchi, Judy E. Anderson, Ryuichi Tatsumi
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Journal Title
Physiological Reports
Volume: 3
Issue: 9
Pages: e12553-e12553
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Implication of anti-inflammatory macrophages in regenerative moto-neuritogenesis: Promotion of myoblast migration and neural chemorepellent semaphorin 3A expression in injured muscle.2014
Author(s)
Sakaguchi S, Shono J, Suzuki T, Shoko S, Anderson JE, Do MKQ, Ohtsubo H, Mizunoya W, Sato Y, Nakamura M, Furuse M, Yamada K, Ikeuchi Y, Tatsumi R.
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Journal Title
International Journal of Biochemistry and Cell Biology
Volume: 52
Pages: 272-285
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Myogenic stem cells isolated from soleus muscle may autonomously form slow-twitch fibers via Sema3A signaling.2016
Author(s)
Takahiro Suzuki, Yu-ki Ohya, Shin-ichiro Nishimatsu, Kumiko Terada, Naoki Katase, Hideaki Ohtsubo, Wataru Mizunoya, Ken Kobayashi, Tsutomu Nohno, Takanori Nishimura, Ryuichi Tatsumi
Organizer
The 17th Asian-Australasian Association of Animal Production Societies Animal Science Congress
Place of Presentation
Kyushu Sangyo University (福岡県・福岡市)
Year and Date
2016-08-22
Related Report
Int'l Joint Research
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[Presentation] Sema3Aはemerin 発現を阻害することで筋特異的因子Pax7およびMyf5 発現を増加させ、筋芽細胞の増殖能を上昇させる2016
Author(s)
Mulan, Wataru Mizunoya, Ryuichi Tatsumi, Yoshihide Ikeuchi, Mako Nakamura
Organizer
Molecular Mechanisms Modulating Skeletal Muscle Development and Homeostasis in Health and Disease
Place of Presentation
Asilomar Conference Grounds, Pacific Grove (United States of America)
Year and Date
2016-06-09
Related Report
Int'l Joint Research
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[Presentation] Anti-inflammatory macrophages implicate in regenerative moto-neuritogenesis, by promoting myoblast migration and Sema3A expression.2014
Author(s)
Sakaguchi, S.,* Shono, J.,* Suzuki, T.,* Sawano, S., Anderson, J.E., Do, M.-K.Q., Ohtsubo, H., Mizunoya, W., Nakamura, M., Furuse, M., Ikeuchi, Y., and Tatsumi, R. (*equal contributors)
Organizer
Animal Science Congress 2014 of the Asian-Australian Association of Animal Production Societies (AAAP)
Place of Presentation
Universitas Gadjah Mada, Indonesia
Year and Date
2014-11-10 – 2014-11-14
Related Report
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[Presentation] Functional interaction between Sema3A and Pax7 in proliferation and differentiation of myoblasts.2014
Author(s)
Mulan, Nakamura, M., Suzuki, T., Mizunoya, W., Ojima, K., Tatsumi, R. and Ikeuchi, Y.
Organizer
International Symposium on Agriculture, Forestry, Environment and Life Sciences in Asia, 2014 (AFELiSA'14)
Place of Presentation
Ladena Condominium, Korea
Year and Date
2014-10-28 – 2014-10-31
Related Report
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[Presentation] M2 macrophages may implicate in regenerative moto-neuritogenesis, by promoting myoblast migration and Sema3A expression.2014
Author(s)
Tatsumi, R.,* Sakaguchi, S.,* Shono, J.,* Suzuki, T.,* Sawano, S., Anderson, J.E., Do, M.-K.Q., Ohtsubo, H., Mizunoya, W., Nakamura, M., Furuse, M., and Ikeuchi, Y. (*equal contributors)
Organizer
2014 FASEB Science Research Conference on “Skeletal Muscle Satellite and Stem Cells”
Place of Presentation
Steamboat Springs, CO, USA
Year and Date
2014-07-20 – 2014-07-25
Related Report
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[Presentation] APOBEC2 deficiency up-regulates myoblast differentiation.2014
Author(s)
Ohtsubo, H., Sato, Y., Suzuki, T., Mizunoya, W., Nakamura, M., Tatsumi, R., and Ikeuchi, Y.
Organizer
2014 FASEB Science Research Conference on “Skeletal Muscle Satellite and Stem Cells”
Place of Presentation
Steamboat Springs, CO, USA
Year and Date
2014-07-20 – 2014-07-25
Related Report
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[Presentation] Sema3A secreted from satellite cells promotes slow-twitch fiber generation.2014
Author(s)
Suzuki, T., Ohya, Y., Ojima, K., Mizunoya, W., Sawano, S., Ohtsubo, H., Nishimatsu, S., Anderson, J. E., Do, M.-K. Q., Nakamura, M., Furuse, M., Ikeuchi, Y., Nohno, T., and Tatsumi, R.
Organizer
2014 FASEB Science Research Conference on “Skeletal Muscle Satellite and Stem Cells”
Place of Presentation
Steamboat Springs, CO, USA
Year and Date
2014-07-20 – 2014-07-25
Related Report
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