| Budget Amount *help |
¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
|
|---|
| Outline of Final Research Achievements |
Muscles having abundant slow fiber type exhibit good meat quality and tenderness. Activation of peroxisome proliferator-activated receptor (PPAR)delta is thought to induce fast-to-slow fiber type transition. Here, we measured and searched various PPARdelta agonistic activities from various agricultural products and by-products. We found the extracts of both Yukireitake mushroom and the mushroom bed showed potent PPARdelta agonistic activities. The expression level of PPARdelta target genes after the administration of these extracts tended to be up-regulated dose-dependently via interperitoneal injection. Meanwhile, these activities were diminished when orally injected. Thus, to obtain the PPARdelta agonistic activities of Yukireitake mushroom or mushroom bed, it is needed to find a way to avoid the effects of a digestive tract.
|
