| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
Synthetic studies of polyfunctionalized natural products with highly-fused ring systems were conducted, and total syntheses of daphenylline and lycopalhine A were accomplished. The synthesis of daphenylline features intramolecular cycloaddition of an azomethine ylide as well as a Claisen rearrangement. In these reactions, the stereochemistries were remotely controlled by the characteristic conformation of the DEF tricyclic core. The synthesis of lydopalhine A features construction of the tricyclic system via cleavage of a cyclopropane ring and a subsequent intramolecular Michael addition. We also carried out synthetic studies of yuzurimine and obtained a key intermediate for the total synthesis, which has a tetrasubstituted C-C double bond in the [5-5] bicyclic system.
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