Mechanism of bacterial homeostasis mediated by transporters and development of new therapeutic strategies to control infectious diseases
| Project/Area Number |
26713004
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Fiscal Year 2015: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2014: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
|
|---|
| Keywords | トランスポーター / 薬剤耐性 / サルモネラ / 大腸菌 / 緑膿菌 / 遺伝子発現制御 / バイオフィルム / 構造生物 / 多剤耐性 / 細菌 / 阻害剤 / 化学療法 / 抗菌薬 / 免疫 |
|---|
| Outline of Final Research Achievements |
We found that the bile-mediated activation of the acrAB and tolC multidrug efflux genes occurs mainly through transcriptional derepression of ramA in Salmonella. It was revealed that multidrug efflux pumps contribute to E. coli biofilm maintenance. It was discovered that AcrB, AcrD, and MdtABC multidrug efflux systems are involved in enterobactin export. We also investigated the effect of methylglyoxal on multidrug-resistant P. aeruginosa, and roles of Salmonella multidrug efflux pumps in decreased susceptibility to triclosan. The structures of the regulator bound with bile acids were also solved, and we performed the phenotype microarray analysis of the drug efflux systems in Salmonella enterica serovar Typhimurium.
|
Report
(3 results)
Research Products
(49 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] トランスポーター制御による細菌恒常性維持機構の解明と新規治療戦略の開発2014
Author(s)
西野邦彦 、Aixin Yan、林克彦、山崎聖司、福島愛子、松本佳巳、西野美都子、Danny KC Fung, Ma Yongzheng, Sun Jingjing, Gao Xiang, Kai Yong, Deng Ziqing
Organizer
大阪大学国際共同研究促進プログラム報告会
Place of Presentation
大阪
Year and Date
2014-12-09
Related Report
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 膜輸送体制御因子による抗菌性物質認識機構の解明2014
Author(s)
S. Yamasaki, E. Nikaido, R. Nakashima, K. Sakurai, D. Fujiwara, I. Fujii and K. Nishino
Organizer
附置研究所間アライアンスによるナノとマクロをつなぐ物質･デバイス･システム創成戦略プロジェクト平成25年度成果報告会
Place of Presentation
大阪
Year and Date
2014-05-30
Related Report
-
[Presentation] 細菌の膜輸送体2014
Author(s)
西野邦彦
Organizer
いちょう祭大阪大学産業科学研究所一般公開
Place of Presentation
大阪
Year and Date
2014-05-02 – 2014-05-03
Related Report
-
-
